Susan Abbatiello is a research scientist in the Proteomics Platform at the Broad Institute of MIT and Harvard. Her research focuses on the development of tests to measure potential protein biomarkers in the blood for diseases such as cancer. She and her colleagues on the platform’s quantitative team use mass spectrometry to measure molecular weight and amino acid sequences, teasing apart multiple proteins in the highly complex, dynamic mixture that is human blood.
Abbatiello has co-chaired a committee that is part of the National Cancer Institute’s Clinical Proteomic Technology Assessment for Cancer (CPTAC). The verification group, drawn from the Broad and four other centers, developed assays that specifically target cancer-relevant biomarkers.
Abbatiello joined the Broad in 2008 after completing a postdoctoral fellowship at the University of Pittsburgh’s Hillman Cancer Center. She received a Ph.D. in analytical chemistry at the University of Florida and a B.A. in chemistry from the College of the Holy Cross.
Abbatiello SE et al. Automated detection of inaccurate and imprecise transitions in peptide quantification by multiple reaction monitoring mass spectrometry. Clin Chem. 2010 Feb;56(2):291-305. Epub 2009 Dec 18.
Addona TA, Abbatiello SE et al. Multi-site assessment of the precision and reproducibility of multiple reaction monitoring-based measurements of proteins in plasma. Nat Biotechnol. 2009 Jul;27(7):633-41. Epub 2009 Jun 28.
Whiteaker JR, Zhao L, Abbatiello SE et al. Evaluation of large scale quantitative proteomic assay development using peptide affinity-based mass spectrometry. Mol Cell Proteomics. 2011 Apr;10(4):M110.005645. Epub 2011 Jan 18.