Suzanne Jacobs, a research scientist and lab manager for the Altshuler lab in the Broad Institute’s Program in Medical and Population Genetics, works to narrow in on the causal genes that underpin type 2 diabetes through functional genomics. Type 2 diabetes affects more than 25 million people in the United States and has been the subject of many large-scale, genome-wide investigations to identify the genetic roots of the disease. Jacobs’s work begins with a list of genes and genetic variants generated by these studies and employs diverse cellular models and assays to determine how these genes contribute to the disease. The goal is to identify causal genes and variants as well as the cellular pathways and processes that characterize the disease, as these could represent important therapeutic targets for those with or at risk for developing type 2 diabetes.
Before joining the Broad in 2010, Jacobs completed her postdoctoral work in the laboratory of Laura Attardi in the Department of Radiation Oncology at the Stanford University School of Medicine, where she studied the cell death pathway induced by the tumor suppressor protein p53. Jacobs received her B.A. in Biological Sciences from Northwestern University and earned a Ph.D. in Biomedical Sciences from the University of California, San Diego.Select Publications
Jacobs SB, et al. Siva is an apoptosis-selective p53 target gene important for neuronal cell death. Cell Death Differ. 2007 Jul;14(7):1374-85
Basak S, Jacobs SB, et al. The metastasis-associated gene Prl-3 is a p53 target involved in cell-cycle regulation. Mol Cell. 2008 May 9;30(3):303-14.