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Synthesis, cellular evaluation and mechanism-of-action of piperlongumine analogsAdams, DJ, Dai M., Pellegrino G., Wagner BK, Stern AM, Shamji AF, and Schreiber SL, (Submitted) Read More / View Supplemental Materials
2015
Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53.Yoon, KW, Byun S., Kwon E., Hwang SY, Chu K., Hiraki M., Jo SH, Weins A., Hakroush S., Cebulla A., Sykes DB, Greka A., Mundel P., Fisher DE, Mandinova A., and Lee SW Science (New York, N.Y.), 2015/07/31, Volume 349, Issue 6247, (2015) Read More / View Supplemental Materials
Abstract
S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction.Yang, L., Calay ES, Fan J., Arduini A., Kunz RC, Gygi SP, Yalcin A., Fu S., and Hotamisligil GS Science (New York, N.Y.), 2015/07/31, Volume 349, Issue 6247, p.500-506, (2015) Read More / View Supplemental Materials
Abstract
Growth dynamics of gut microbiota in health and disease inferred from single metagenomic samples.Korem, T., Zeevi D., Suez J., Weinberger A., Avnit-Sagi T., Pompan-Lotan M., Matot E., Jona G., Harmelin A., Cohen N., Sirota-Madi A., Thaiss CA, Pevsner-Fischer M., Sorek R., Xavier R., Elinav E., and Segal E. Science (New York, N.Y.), 2015/07/30, (2015) Read More / View Supplemental Materials
Abstract
The Stress-Induced Atf3-Gelsolin Cascade Underlies Dendritic Spine Deficits in Neuronal Models of Tuberous Sclerosis Complex.Nie, D., Chen Z., Ebrahimi-Fakhari D., Di Nardo A., Julich K., Robson VK, Cheng YC, Woolf CJ, Heiman M., and Sahin M. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015/07/29, Volume 35, Issue 30, p.10762-72, (2015) Read More / View Supplemental Materials
Abstract
A targeted functional RNAi screen uncovers Glypican 5 as an entry factor for hepatitis B and D viruses.Verrier, ER, Colpitts CC, Bach C., Heydmann L., Weiss A., Renaud M., Durand SC, Habersetzer F., Durantel D., Abou-Jaoudé G., López Ledesma MM, Felmlee DJ, Soumillon M., Croonenborghs T., Pochet N., Nassal M., Schuster C., Brino L., Sureau C., Zeisel MB, et al. Hepatology (Baltimore, Md.), 2015/07/29, (2015) Read More / View Supplemental Materials
Abstract
FermiKit: assembly-based variant calling for Illumina resequencing data.Li, H. Bioinformatics (Oxford, England), 2015/07/27, (2015) Read More / View Supplemental Materials
Abstract
CXCR3 Polymorphism and Expression Associate with Spontaneous Preterm Birth.Karjalainen, MK, Ojaniemi M., Haapalainen AM, Mahlman M., Salminen A., Huusko JM, Määttä TA, Kaukola T., Anttonen J., Ulvila J., Haataja R., Teramo K., Kingsmore SF, Palotie A., Muglia LJ, Rämet M., and Hallman M. Journal of immunology (Baltimore, Md. : 1950), 2015/07/24, (2015) Read More / View Supplemental Materials
Abstract
Multiple cell and population-level interactions with mouse embryonic stem cell heterogeneity.Cannon, D., Corrigan AM, Miermont A., McDonel P., and Chubb JR Development (Cambridge, England), 2015/07/24, (2015) Read More / View Supplemental Materials
Abstract
Genotype-specific variation in West Nile virus dispersal in California.Duggal, NK, Reisen WK, Fang Y., Newman RM, Yang X., Ebel GD, and Brault AC Virology, 2015/07/23, Volume 485, p.79-85, (2015) Read More / View Supplemental Materials
Abstract
Dynamics of Tumor Heterogeneity Derived from Clonal Karyotypic Evolution.Laughney, AM, Elizalde S., Genovese G., and Bakhoum SF Cell reports, 2015/07/22, (2015) Read More / View Supplemental Materials
Abstract
Hypoxia-Mediated Increases in l-2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress.Oldham, WM, Clish CB, Yang Y., and Loscalzo J. Cell metabolism, 2015/07/22, (2015) Read More / View Supplemental Materials
Abstract
Protein Crowding Is a Determinant of Lipid Droplet Protein Composition.Kory, N., Thiam AR, Farese RV Jr, and Walther TC Developmental cell, 2015/07/22, (2015) Read More / View Supplemental Materials
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Steroid sex hormones, sex hormone binding globulin and diabetes incidence in the Diabetes Prevention Program.Mather, KM, Kim C., Christophi CA, Aroda VR, Knowler WC, Edelstein SE, Florez JC, Labrie F., Kahn SE, Goldberg RB, Barrett-Connor E., and Diabetes Prevention Program Research Group The Journal of clinical endocrinology and metabolism, 2015/07/22, p.jc20152328, (2015) Read More / View Supplemental Materials
Abstract
Analysis of exome sequence in 604 trios for recessive genotypes in schizophrenia.Rees, E., Kirov G., Walters JT, Richards AL, Howrigan D., Kavanagh DH, Pocklington AJ, Fromer M., Ruderfer DM, Georgieva L., Carrera N., Gormley P., Palta P., Williams H., Dwyer S., Johnson JS, Roussos P., Barker DD, Banks E., Milanova V., et al. Translational psychiatry, 2015/07/21, Volume 5, p.e607, (2015) Read More / View Supplemental Materials
Abstract
Functional genomics identifies negative regulatory nodes controlling phagocyte oxidative burst.Graham, DB, Becker CE, Doan A., Goel G., Villablanca EJ, Knights D., Mok A., Ng AC, Doench JG, Root DE, Clish CB, and Xavier RJ Nature communications, 2015/07/21, Volume 6, p.7838, (2015) Read More / View Supplemental Materials
Abstract
Genetic evidence for two founding populations of the Americas.Skoglund, P., Mallick S., Bortolini MC, Chennagiri N., Hünemeier T., Petzl-Erler ML, Salzano FM, Patterson N., and Reich D. Nature, 2015/07/21, (2015) Read More / View Supplemental Materials
Abstract
The promise and peril of chemical probes.Arrowsmith, CH, Audia JE, Austin C., Baell J., Bennett J., Blagg J., Bountra C., Brennan PE, Brown PJ, Bunnage ME, Buser-Doepner C., Campbell RM, Carter AJ, Cohen P., Copeland RA, Cravatt B., Dahlin JL, Dhanak D., Edwards AM, Frye SV, et al. Nature chemical biology, 2015/07/21, Volume 11, Issue 8, p.536-41, (2015) Read More / View Supplemental Materials
A genetic basis of variation in eccrine sweat gland and hair follicle density.Kamberov, YG, Karlsson EK, Kamberova GL, Lieberman DE, Sabeti PC, Morgan BA, and Tabin CJ Proceedings of the National Academy of Sciences of the United States of America, 2015/07/20, (2015) Read More / View Supplemental Materials
Abstract
Paired exome analysis of Barrett's esophagus and adenocarcinoma.Stachler, MD, Taylor-Weiner A., Peng S., McKenna A., Agoston AT, Odze RD, Davison JM, Nason KS, Loda M., Leshchiner I., Stewart C., Stojanov P., Seepo S., Lawrence MS, Ferrer-Torres D., Lin J., Chang AC, Gabriel SB, Lander E. S., Beer DG, et al. Nature genetics, 2015/07/20, (2015) Read More / View Supplemental Materials
Abstract
Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics.Kuo, SY, Castoreno AB, Aldrich LN, Lassen KG, Goel G., Dančík V., Kuballa P., Latorre I., Conway KL, Sarkar S., Maetzel D., Jaenisch R., Clemons PA, Schreiber SL, Shamji AF, and Xavier RJ Proceedings of the National Academy of Sciences of the United States of America, 2015/07/20, (2015) Read More / View Supplemental Materials
Abstract
GenomeConnect: Matchmaking Between Patients, Clinical Laboratories and Researchers to Improve Genomic Knowledge.Kirkpatrick, BE, Riggs ER, Azzariti DR, Miller VR, Ledbetter DH, Miller DT, Rehm H., Martin CL, Faucett WA, and ClinGen Resource Human mutation, 2015/07/16, (2015) Read More / View Supplemental Materials
Abstract
Integrative Analyses of Human Reprogramming Reveal Dynamic Nature of Induced Pluripotency.Cacchiarelli, D., Trapnell C., Ziller MJ, Soumillon M., Cesana M., Karnik R., Donaghey J., Smith ZD, Ratanasirintrawoot S., Zhang X., Ho Sui SJ, Wu Z., Akopian V., Gifford CA, Doench J., Rinn JL, Daley GQ, Meissner A., Lander E. S., and Mikkelsen TS Cell, 2015/07/16, Volume 162, Issue 2, p.412-24, (2015) Read More / View Supplemental Materials
Abstract
Revisited HLA and non-HLA genetics of Takayasu arteritis-where are we?Terao, C. Journal of human genetics, 2015/07/16, (2015) Read More / View Supplemental Materials
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Body Mass Index, Genetic Susceptibility, and Risk of Complications Among Individuals with Crohn's Disease.Pringle, PL, Stewart KO, Peloquin JM, Sturgeon HC, Nguyen D., Sauk J., Garber JJ, Yajnik V., Ananthakrishnan AN, Chan AT, Xavier RJ, and Khalili H. Inflammatory bowel diseases, 2015/07/15, (2015) Read More / View Supplemental Materials
Abstract
Chromerid genomes reveal the evolutionary path from photosynthetic algae to obligate intracellular parasites.Woo, YH, Ansari H., Otto TD, Klinger CM, Kolisko M., Michálek J., Saxena A., Shanmugam D., Tayyrov A., Veluchamy A., Ali S., Bernal A., Del Campo J., Cihlář J., Flegontov P., Gornik SG, Hajdušková E., Horák A., Janouškovec J., Katris NJ, et al. eLife, 2015/07/15, Volume 4, (2015) Read More / View Supplemental Materials
Abstract
Extending the phenotypic spectrum of RBFOX1 deletions: Sporadic focal epilepsy.Lal, D., Pernhorst K., Klein KM, Reif P., Tozzi R., Toliat MR, Winterer G., Neubauer B., Nürnberg P., Rosenow F., Becker F., Lerche H., Kunz WS, Kurki MI, Hoffmann P., Becker AJ, Perucca E., Zara F., Sander T., and Weber YG Epilepsia, 2015/07/15, (2015) Read More / View Supplemental Materials
Abstract
A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks.Parnas, O., Jovanovic M., Eisenhaure TM, Herbst RH, Dixit A., Ye CJ, Przybylski D., Platt RJ, Tirosh I., Sanjana NE, Shalem O., Satija R., Raychowdhury R., Mertins P., Carr SA, Zhang F., Hacohen N., and Regev A. Cell, 2015/07/15, (2015) Read More / View Supplemental Materials
Abstract
CCL2 Promotes Colorectal Carcinogenesis by Enhancing Polymorphonuclear Myeloid-Derived Suppressor Cell Population and Function.Chun, E., Lavoie S., Michaud M., Gallini CA, Kim J., Soucy G., Odze R., Glickman JN, and Garrett WS Cell reports, 2015/07/14, Volume 12, Issue 2, p.244-257, (2015) Read More / View Supplemental Materials
Abstract
Near universal detection of alterations in CTNNB1 and Wnt pathway regulators in desmoid-type fibromatosis by whole-exome sequencing and genomic analysis.Crago, AM, Chmielecki J., Rosenberg M., O'Connor R., Byrne C., Wilder FG, Thorn K., Agius P., Kuk D., Socci ND, Qin LX, Meyerson M., Hameed M., and Singer S. Genes, chromosomes & cancer, 2015/07/14, (2015) Read More / View Supplemental Materials
Abstract
Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial Type II topoisomerases.Basarab, GS, Kern GH, McNulty J., Mueller JP, Lawrence K., Vishwanathan K., Alm RA, Barvian K., Doig P., Galullo V., Gardner H., Gowravaram M., Huband M., Kimzey A., Morningstar M., Kutschke A., Lahiri SD, Perros M., Singh R., Schuck VJ, et al. Scientific reports, 2015/07/14, Volume 5, p.11827, (2015) Read More / View Supplemental Materials
Abstract
Activity of the Type II JAK2 Inhibitor CHZ868 in B Cell Acute Lymphoblastic Leukemia.Wu, SC, Li LS, Kopp N., Montero J., Chapuy B., Yoda A., Christie AL, Liu H., Christodoulou A., van Bodegom D., van der Zwet J., Layer JV, Tivey T., Lane AA, Ryan JA, Ng SY, DeAngelo DJ, Stone RM, Steensma D., Wadleigh M., et al. Cancer cell, 2015/07/13, Volume 28, Issue 1, p.29-41, (2015) Read More / View Supplemental Materials
Abstract
Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk.Hu, X., Deutsch AJ, Lenz TL, Onengut-Gumuscu S., Han B., Chen WM, Howson JM, Todd JA, de Bakker PI, Rich SS, and Raychaudhuri S. Nature genetics, 2015/07/13, (2015) Read More / View Supplemental Materials
Abstract
Role of Autophagy in the Maintenance of Intestinal Homeostasis.Baxt, LA, and Xavier RJ Gastroenterology, 2015/07/10, (2015) Read More / View Supplemental Materials
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Association of Polymerase e-Mutated and Microsatellite-Instable Endometrial Cancers With Neoantigen Load, Number of Tumor-Infiltrating Lymphocytes, and Expression of PD-1 and PD-L1.Howitt, BE, Shukla SA, Sholl LM, Ritterhouse LL, Watkins JC, Rodig S., Stover E., Strickland KC, D'Andrea AD, Wu CJ, Matulonis UA, and Konstantinopoulos PA JAMA oncology, 2015/07/09, (2015) Read More / View Supplemental Materials
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Data analysis: Create a cloud commons.Stein, LD, Knoppers BM, Campbell P., Getz G., and Korbel JO Nature, 2015/07/09, Volume 523, Issue 7559, p.149-51, (2015) Read More / View Supplemental Materials
Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS.Krönke, J., Fink EC, Hollenbach PW, MacBeth KJ, Hurst SN, Udeshi ND, Chamberlain PP, Mani D. R., Man HW, Gandhi AK, Svinkina T., Schneider RK, McConkey M., Järås M., Griffiths E., Wetzler M., Bullinger L., Cathers BE, Carr SA, Chopra R., et al. Nature, 2015/07/09, Volume 523, Issue 7559, p.183-8, (2015) Read More / View Supplemental Materials
Abstract
Cross-sectional examination of metabolites and metabolic phenotypes in uremia.Kalim, S., Clish CB, Deferio JJ, Ortiz G., Moffet AS, Gerszten RE, Thadhani R., and Rhee EP BMC nephrology, 2015/07/07, Volume 16, p.98, (2015) Read More / View Supplemental Materials
Abstract
Deficiency of UBE2T, the E2 Ubiquitin Ligase Necessary for FANCD2 and FANCI Ubiquitination, Causes FA-T Subtype of Fanconi Anemia.Rickman, KA, Lach FP, Abhyankar A., Donovan FX, Sanborn EM, Kennedy JA, Sougnez C., Gabriel SB, Elemento O., Chandrasekharappa SC, Schindler D., Auerbach AD, and Smogorzewska A. Cell reports, 2015/07/07, Volume 12, Issue 1, p.35-41, (2015) Read More / View Supplemental Materials
Abstract
The Extracellular Matrix: Tools and Insights for the "Omics" Era.Naba, A., Clauser KR, Ding H., Whittaker CA, Carr SA, and Hynes R. O. Matrix biology : journal of the International Society for Matrix Biology, 2015/07/07, (2015) Read More / View Supplemental Materials
Abstract
Quantitative proteomics suggests decrease in the secretogranin-1 cerebrospinal fluid levels during the disease course of multiple sclerosis.Kroksveen, AC, Jaffe JD, Aasebø E., Barsnes H., Bjørlykke Y., Franciotta D., Keshishian H., Myhr KM, Opsahl JA, van Pesch V., Teunissen CE, Torkildsen Ø., Ulvik RJ, Vethe H., Carr SA, and Berven FS Proteomics, 2015/07/07, (2015) Read More / View Supplemental Materials
Abstract
Genome-Scale Protein Microarray Comparison of Human Antibody Responses in Plasmodium vivax Relapse and Reinfection.Chuquiyauri, R., Molina DM, Moss EL, Wang R., Gardner MJ, Brouwer KC, Torres S., Gilman RH, Llanos-Cuentas A., Neafsey DE, Felgner P., Liang X., and Vinetz JM The American journal of tropical medicine and hygiene, 2015/07/06, (2015) Read More / View Supplemental Materials
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Combined Whole Methylome and Genomewide Association Study Implicates CNTN4 in Alcohol Use.Clark, SL, Aberg KA, Nerella S., Kumar G., McClay JL, Chen W., Xie LY, Harada A., Shabalin AA, Gao G., Bergen SE, Hultman CM, Magnusson PK, Sullivan PF, and van den Oord EJ Alcoholism, clinical and experimental research, 2015/07/04, (2015) Read More / View Supplemental Materials
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CSER and eMERGE: current and potential state of the display of genetic information in the electronic health record.Shirts, BH, Salama JS, Aronson SJ, Chung WK, Gray SW, Hindorff LA, Jarvik GP, Plon SE, Stoffel EM, Tarczy-Hornoch PZ, Van Allen EM, Weck KE, Chute CG, Freimuth RR, Grundmeier RW, Hartzler AL, Li R., Peissig PL, Peterson JF, Rasmussen LV, et al. Journal of the American Medical Informatics Association : JAMIA, 2015/07/03, (2015) Read More / View Supplemental Materials
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Biomarkers in multiple sclerosis.Housley, WJ, Pitt D., and Hafler DA Clinical immunology (Orlando, Fla.), 2015/07/02, (2015) Read More / View Supplemental Materials
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Disentangling the Effects of Colocalizing Genomic Annotations to Functionally Prioritize Non-coding Variants within Complex-Trait Loci.Trynka, G., Westra HJ, Slowikowski K., Hu X., Xu H., Stranger BE, Klein RJ, Han B., and Raychaudhuri S. American journal of human genetics, 2015/07/02, Volume 97, Issue 1, p.139-52, (2015) Read More / View Supplemental Materials
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From Dish to Bedside: Lessons Learned While Translating Findings from a Stem Cell Model of Disease to a Clinical Trial.McNeish, J., Gardner JP, Wainger BJ, Woolf CJ, and Eggan K. Cell stem cell, 2015/07/02, Volume 17, Issue 1, p.8-10, (2015) Read More / View Supplemental Materials
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Correction for hwang et Al., polyomavirus small T antigen interacts with yes-associated protein to regulate cell survival and differentiation.Hwang, JH, Pores Fernando AT, Faure N., Andrabi S., Adelmant G., Hahn WC, Marto JA, Schaffhausen BS, and Roberts TM Journal of virology, 2015/07/01, Volume 89, Issue 13, p.6971, (2015) Read More / View Supplemental Materials
CRISPR-Cas9: Prospects and Challenges.Zhang, F. Human gene therapy, 2015/07/01, Volume 26, Issue 7, p.409-10, (2015) Read More / View Supplemental Materials
Directional dominance on stature and cognition in diverse human populations.Joshi, PK, Esko T., Mattsson H., Eklund N., Gandin I., Nutile T., Jackson AU, Schurmann C., Smith AV, Zhang W., Okada Y., Stančáková A., Faul JD, Zhao W., Bartz TM, Concas MP, Franceschini N., Enroth S., Vitart V., Trompet S., et al. Nature, 2015/07/01, (2015) Read More / View Supplemental Materials
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Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation.Horikoshi, M., Mӓgi R., van de Bunt M., Surakka I., Sarin AP, Mahajan A., Marullo L., Thorleifsson G., Hӓgg S., Hottenga JJ, Ladenvall C., Ried JS, Winkler TW, Willems SM, Pervjakova N., Esko T., Beekman M., Nelson CP, Willenborg C., Wiltshire S., et al. PLoS genetics, 2015/07/01, Volume 11, Issue 7, p.e1005230, (2015) Read More / View Supplemental Materials
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An ecosystem of cancer cell line factories to support a cancer dependency map.Boehm, JS, and Golub T. R. Nature reviews. Genetics, 2015/07/01, Volume 16, Issue 7, p.373-4, (2015) Read More / View Supplemental Materials
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Metabolic Rewiring by Oncogenic BRAF V600E Links Ketogenesis Pathway to BRAF-MEK1 Signaling.Kang, HB, Fan J., Lin R., Elf S., Ji Q., Zhao L., Jin L., Seo JH, Shan C., Arbiser JL, Cohen C., Brat D., Miziorko HM, Kim E., Abdel-Wahab O., Merghoub T., Fröhling S., Scholl C., Tamayo P., Barbie DA, et al. Molecular cell, 2015/07/01, (2015) Read More / View Supplemental Materials
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Integrated Genomics of Crohn's Disease Risk Variant Identifies a Role for CLEC12A in Antibacterial Autophagy.Begun, J., Lassen KG, Jijon HB, Baxt LA, Goel G., Heath RJ, Ng A., Tam JM, Kuo SY, Villablanca EJ, Fagbami L., Oosting M., Kumar V., Schenone M., Carr SA, Joosten LA, Vyas JM, Daly M. J., Netea MG, Brown GD, et al. Cell reports, 2015/06/30, Volume 11, Issue 12, p.1905-1918, (2015) Read More / View Supplemental Materials
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The RSK Inhibitor BIX02565 Limits Cardiac Ischemia/Reperfusion Injury.Shi, X., O'Neill MM, MacDonnell S., Brookes PS, Yan C., and Berk BC Journal of cardiovascular pharmacology and therapeutics, 2015/06/30, (2015) Read More / View Supplemental Materials
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Development of a High-Throughput Functional Screen Using Nanowell-Assisted Cell Patterning.Ozkumur, AY, Goods BA, and Love JC Small (Weinheim an der Bergstrasse, Germany), 2015/06/29, (2015) Read More / View Supplemental Materials
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Comprehensive, Integrative Genomic Analysis of Diffuse Lower-Grade Gliomas.Cancer Genome Atlas Research, Network, Brat DJ, Verhaak RG, Aldape KD, Yung WK, Salama SR, Cooper LA, Rheinbay E., Miller CR, Vitucci M., Morozova O., Robertson AG, Noushmehr H., Laird PW, Cherniack AD, Akbani R., Huse JT, Ciriello G., Poisson LM, Barnholtz-Sloan JS, et al. The New England journal of medicine, 2015/06/25, Volume 372, Issue 26, p.2481-98, (2015) Read More / View Supplemental Materials
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Rare Coding Variation and Risk of Intracerebral Hemorrhage.Radmanesh, F., Falcone GJ, Anderson CD, McWilliams D., Devan WJ, Brown WM, Battey TW, Ayres AM, Raffeld MR, Schwab K., Sun G., Deka R., Viswanathan A., Goldstein JN, Greenberg SM, Tirschwell DL, Silliman SL, Selim M., Meschia JF, Brown DL, et al. Stroke; a journal of cerebral circulation, 2015/06/25, (2015) Read More / View Supplemental Materials
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Distinct lineages of Ebola virus in Guinea during the 2014 West African epidemic.Simon-Loriere, E., Faye O., Faye O., Koivogui L., Magassouba N., Keita S., Thiberge JM, Diancourt L., Bouchier C., Vandenbogaert M., Caro V., Fall G., Buchmann JP, Matranga CB, Sabeti PC, Manuguerra JC, Holmes EC, and Sall AA Nature, 2015/06/24, (2015) Read More / View Supplemental Materials
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Linked genetic variants on chromosome 10 control ear morphology and body mass among dog breeds.Webster, MT, Kamgari N., Perloski M., Hoeppner MP, Axelsson E., Hedhammar Å., Pielberg G., and Lindblad-Toh K. BMC genomics, 2015/06/23, Volume 16, p.474, (2015) Read More / View Supplemental Materials
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Antibiotic efficacy is linked to bacterial cellular respiration.Lobritz, MA, Belenky P., Porter CB, Gutierrez A., Yang JH, Schwarz EG, Dwyer DJ, Khalil AS, and Collins JJ Proceedings of the National Academy of Sciences of the United States of America, 2015/06/22, (2015) Read More / View Supplemental Materials
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An early modern human from Romania with a recent Neanderthal ancestor.Fu, Q., Hajdinjak M., Moldovan OT, Constantin S., Mallick S., Skoglund P., Patterson N., Rohland N., Lazaridis I., Nickel B., Viola B., Prüfer K., Meyer M., Kelso J., Reich D., and Pääbo S. Nature, 2015/06/22, (2015) Read More / View Supplemental Materials
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Engineered CRISPR-Cas9 nucleases with altered PAM specificities.Kleinstiver, BP, Prew MS, Tsai SQ, Topkar VV, Nguyen NT, Zheng Z., Gonzales AP, Li Z., Peterson RT, Yeh JJ, Aryee MJ, and Joung JK Nature, 2015/06/22, (2015) Read More / View Supplemental Materials
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Interactions between amino-acid-defined MHC class II variants and smoking for seropositive rheumatoid arthritis.Kim, K., Jiang X., Cui J., Lu B., Costenbader KH, Sparks JA, Bang SY, Lee HS, Okada Y., Raychaudhuri S., Alfredsson L., Bae SC, Klareskog L., and Karlson EW Arthritis & rheumatology (Hoboken, N.J.), 2015/06/22, (2015) Read More / View Supplemental Materials
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Structural forms of the human amylase locus and their relationships to SNPs, haplotypes and obesity.Usher, CL, Handsaker RE, Esko T., Tuke MA, Weedon MN, Hastie AR, Cao H., Moon JE, Kashin S., Fuchsberger C., Metspalu A., Pato CN, Pato MT, McCarthy MI, Boehnke M., Altshuler DM, Frayling TM, Hirschhorn JN, and McCarroll SA Nature genetics, 2015/06/22, (2015) Read More / View Supplemental Materials
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Marrying microfluidics and microwells for parallel, high-throughput single-cell genomics.Wadsworth MH, 2nd, Hughes TK, and Shalek AK Genome biology, 2015/06/20, Volume 16, Issue 1, p.129, (2015) Read More / View Supplemental Materials
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Cooperation for Better Inhibiting.Novoa, EM, and Ribas de Pouplana L. Chemistry & biology, 2015/06/18, Volume 22, Issue 6, p.685-6, (2015) Read More / View Supplemental Materials
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Ebola Virus Epidemiology, Transmission, and Evolution during Seven Months in Sierra Leone.Park, DJ, Dudas G., Wohl S., Goba A., Whitmer SL, Andersen KG, Sealfon RS, Ladner JT, Kugelman JR, Matranga CB, Winnicki SM, Qu J., Gire SK, Gladden-Young A., Jalloh S., Nosamiefan D., Yozwiak NL, Moses LM, Jiang PP, Lin AE, et al. Cell, 2015/06/18, Volume 161, Issue 7, p.1516-26, (2015) Read More / View Supplemental Materials
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Single Amino Acid Variation Underlies Species-Specific Sensitivity to Amphibian Skin-Derived Opioid-like Peptides.Vardy, E., Sassano MF, Rennekamp AJ, Kroeze WK, Mosier PD, Westkaemper RB, Stevens CW, Katritch V., Stevens RC, Peterson RT, and Roth BL Chemistry & biology, 2015/06/18, Volume 22, Issue 6, p.764-75, (2015) Read More / View Supplemental Materials
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miRNA-embedded shRNAs for lineage-specific BCL11A knockdown and hemoglobin F induction.Guda, S., Brendel C., Renella R., Du P., Bauer DE, Canver MC, Grenier JK, Grimson AW, Kamran SC, Thornton J., De Boer H., Root DE, Milsom MD, Orkin SH, Gregory RI, and Williams DA Molecular therapy : the journal of the American Society of Gene Therapy, 2015/06/17, (2015) Read More / View Supplemental Materials
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Paired-Duplication Signatures Mark Cryptic Inversions and Other Complex Structural Variation.Brand, H., Collins RL, Hanscom C., Rosenfeld JA, Pillalamarri V., Stone MR, Kelley F., Mason T., Margolin L., Eggert S., Mitchell E., Hodge JC, Gusella JF, Sanders SJ, and Talkowski ME American journal of human genetics, 2015/06/17, (2015) Read More / View Supplemental Materials
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Phenotypic assays identify azoramide as a small-molecule modulator of the unfolded protein response with antidiabetic activity.Fu, S., Yalcin A., Lee GY, Li P., Fan J., Arruda AP, Pers BM, Yilmaz M., Eguchi K., and Hotamisligil GS Science translational medicine, 2015/06/17, Volume 7, Issue 292, p.292ra98, (2015) Read More / View Supplemental Materials
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Functionally Distinct Subsets of Lineage-Biased Multipotent Progenitors Control Blood Production in Normal and Regenerative Conditions.Pietras, EM, Reynaud D., Kang YA, Carlin D., Calero-Nieto FJ, Leavitt AD, Stuart JM, Göttgens B., and Passegué E. Cell stem cell, 2015/06/16, (2015) Read More / View Supplemental Materials
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Global and local ancestry in African-Americans: Implications for Alzheimer's disease risk.Hohman, TJ, Cooke-Bailey JN, Reitz C., Jun G., Naj A., Beecham GW, Liu Z., Carney RM, Vance JM, Cuccaro ML, Rajbhandary R., Vardarajan BN, Wang LS, Valladares O., Lin CF, Larson EB, Graff-Radford NR, Evans D., De Jager PL, Crane PK, et al. Alzheimer's & dementia : the journal of the Alzheimer's Association, 2015/06/16, (2015) Read More / View Supplemental Materials
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The MicroRNA-132 and MicroRNA-212 Cluster Regulates Hematopoietic Stem Cell Maintenance and Survival with Age by Buffering FOXO3 Expression.Mehta, A., Zhao JL, Sinha N., Marinov GK, Mann M., Kowalczyk MS, Galimidi RP, Du X., Erikci E., Regev A., Chowdhury K., and Baltimore D. Immunity, 2015/06/16, Volume 42, Issue 6, p.1021-32, (2015) Read More / View Supplemental Materials
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Sex and parasites: genomic and transcriptomic analysis of Microbotryum lychnidis-dioicae, the biotrophic and plant-castrating anther smut fungus.Perlin, MH, Amselem J., Fontanillas E., Toh SS, Chen Z., Goldberg J., Duplessis S., Henrissat B., Young S., Zeng Q., Aguileta G., Petit E., Badouin H., Andrews J., Razeeq D., Gabaldón T., Quesneville H., Giraud T., Hood ME, Schultz DJ, et al. BMC genomics, 2015/06/16, Volume 16, Issue 1, p.461, (2015) Read More / View Supplemental Materials
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Somatic Cell Fusions Reveal Extensive Heterogeneity in Basal-like Breast Cancer.Su, Y., Subedee A., Bloushtain-Qimron N., Savova V., Krzystanek M., Li L., Marusyk A., Tabassum DP, Zak A., Flacker MJ, Li M., Lin JJ, Sukumar S., Suzuki H., Long H., Szallasi Z., Gimelbrant A., Maruyama R., and Polyak K. Cell reports, 2015/06/16, Volume 11, Issue 10, p.1549-63, (2015) Read More / View Supplemental Materials
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In silico phenotyping via co-training for improved phenotype prediction from genotype.Roqueiro, D., Witteveen MJ, Anttila V., Terwindt GM, van den Maagdenberg AM, and Borgwardt K. Bioinformatics (Oxford, England), 2015/06/15, Volume 31, Issue 12, p.i303-i310, (2015) Read More / View Supplemental Materials
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Strand-specific RNA sequencing in Plasmodium falciparum malaria identifies developmentally regulated long non-coding RNA and circular RNA.Broadbent, KM, Broadbent JC, Ribacke U., Wirth D., Rinn JL, and Sabeti PC BMC genomics, 2015/06/13, Volume 16, p.454, (2015) Read More / View Supplemental Materials
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Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels.Draisma, HH, Pool R., Kobl M., Jansen R., Petersen AK, Vaarhorst AA, Yet I., Haller T., Demirkan A., Esko T., Zhu G., Böhringer S., Beekman M., van Klinken JB, Römisch-Margl W., Prehn C., Adamski J., de Craen AJ, van Leeuwen EM, Amin N., et al. Nature communications, 2015/06/12, Volume 6, p.7208, (2015) Read More / View Supplemental Materials
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Protect researchers from harassment.Hyman, SE, and Goldberg ME Science (New York, N.Y.), 2015/06/12, Volume 348, Issue 6240, p.1216-7, (2015) Read More / View Supplemental Materials
Genetic variants associated with autoimmunity drive NFκB signaling and responses to inflammatory stimuli.Housley, WJ, Fernandez SD, Vera K., Murikinati SR, Grutzendler J., Cuerdon N., Glick L., De Jager PL, Mitrovic M., Cotsapas C., and Hafler DA Science translational medicine, 2015/06/10, Volume 7, Issue 291, p.291ra93, (2015) Read More / View Supplemental Materials
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Light-weight reference-based compression of FASTQ data.Zhang, Y., Li L., Yang Y., Yang X., He S., and Zhu Z. BMC bioinformatics, 2015/06/09, Volume 16, Issue 1, p.188, (2015) Read More / View Supplemental Materials
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Reply to Letter.Replogle, JM, and De Jager PL Annals of neurology, 2015/06/09, (2015) Read More / View Supplemental Materials
Host lysozyme-mediated lysis of Lactococcus lactis facilitates delivery of colitis-attenuating superoxide dismutase to inflamed colons.Ballal, SA, Veiga P., Fenn K., Michaud M., Kim JH, Gallini CA, Glickman JN, Quéré G., Garault P., Béal C., Derrien M., Courtin P., Kulakauskas S., Chapot-Chartier MP, van Hylckama Vlieg J., and Garrett WS Proceedings of the National Academy of Sciences of the United States of America, 2015/06/08, (2015) Read More / View Supplemental Materials
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Inference of transcriptional regulation in cancers.Jiang, P., Freedman ML, Liu JS, and Liu XS Proceedings of the National Academy of Sciences of the United States of America, 2015/06/08, (2015) Read More / View Supplemental Materials
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Tracks through the genome to physiological events.Lipscombe, D., Pan JQ, and Schorge S. Experimental physiology, 2015/06/06, (2015) Read More / View Supplemental Materials
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Accurate and Fast Multiple-Testing Correction in eQTL Studies.Sul, JH, Raj T., de Jong S., de Bakker PI, Raychaudhuri S., Ophoff RA, Stranger BE, Eskin E., and Han B. American journal of human genetics, 2015/06/04, Volume 96, Issue 6, p.857-68, (2015) Read More / View Supplemental Materials
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Advancing Biological Understanding and Therapeutics Discovery with Small-Molecule Probes.Schreiber, SL, Kotz JD, Li M., Aubé J., Austin CP, Reed JC, Rosen H., White EL, Sklar LA, Lindsley CW, Alexander BR, Bittker JA, Clemons PA, De Souza A., Foley MA, Palmer M., Shamji AF, Wawer MJ, McManus O., Wu M., et al. Cell, 2015/06/04, Volume 161, Issue 6, p.1252-1265, (2015) Read More / View Supplemental Materials
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Breakpoint mapping by whole genome sequencing identifies PTH2R gene disruption in a patient with midline craniosynostosis and a de novo balanced chromosomal rearrangement.Kim, J., Won HH, Kim Y., Choi JR, Yu N., and Lee KA Journal of medical genetics, 2015/06/04, (2015) Read More / View Supplemental Materials
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Activity-Induced DNA Breaks Govern the Expression of Neuronal Early-Response Genes.Madabhushi, R., Gao F., Pfenning AR, Pan L., Yamakawa S., Seo J., Rueda R., Phan TX, Yamakawa H., Pao PC, Stott RT, Gjoneska E., Nott A., Cho S., Kellis M., and Tsai LH Cell, 2015/06/03, (2015) Read More / View Supplemental Materials
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Brave New Genome.Lander, E. S. The New England journal of medicine, 2015/06/03, (2015) Read More / View Supplemental Materials
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Genetic variants primarily associated with type 2 diabetes are related to coronary artery disease risk.Jansen, H., Loley C., Lieb W., Pencina MJ, Nelson CP, Kathiresan S., Peloso GM, Voight BF, Reilly MP, Assimes TL, Boerwinkle E., Hengstenberg C., Laaksonen R., McPherson R., Roberts R., Thorsteinsdottir U., Peters A., Gieger C., Rawal R., Thompson JR, et al. Atherosclerosis, 2015/06/03, Volume 241, Issue 2, p.419-426, (2015) Read More / View Supplemental Materials
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Novel Findings from CNVs Implicate Inhibitory and Excitatory Signaling Complexes in Schizophrenia.Pocklington, AJ, Rees E., Walters JT, Han J., Kavanagh DH, Chambert KD, Holmans P., Moran JL, McCarroll SA, Kirov G., O'Donovan MC, and Owen MJ Neuron, 2015/06/03, Volume 86, Issue 5, p.1203-14, (2015) Read More / View Supplemental Materials
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CRISPR/Cas9 cleavage of viral DNA efficiently suppresses hepatitis B virus.Ramanan, V., Shlomai A., Cox DB, Schwartz RE, Michailidis E., Bhatta A., Scott DA, Zhang F., Rice CM, and Bhatia SN Scientific reports, 2015/06/02, Volume 5, p.10833, (2015) Read More / View Supplemental Materials
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African Ancestry Analysis and Admixture Genetic Mapping for Proliferative Diabetic Retinopathy in African Americans.Tandon, A., Chen CJ, Penman A., Hancock H., James M., Husain D., Andreoli C., Li X., Kuo JZ, Idowu O., Riche D., Papavasilieou E., Brauner S., Smith SO, Hoadley S., Richardson C., Kieser T., Vazquez V., Chi C., Fernandez M., et al. Investigative ophthalmology & visual science, 2015/06/01, Volume 56, Issue 6, p.3999-4005, (2015) Read More / View Supplemental Materials
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Alzheimer's loci: epigenetic associations and interaction with genetic factors.Chibnik, LB, Yu L., Eaton ML, Srivastava G., Schneider JA, Kellis M., Bennett DA, and De Jager PL Annals of clinical and translational neurology, 2015/06/01, Volume 2, Issue 6, p.636-47, (2015) Read More / View Supplemental Materials
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The association between lower educational attainment and depression owing to shared genetic effects? Results in ~25,000 subjects.Peyrot, WJ, Lee SH, Milaneschi Y., Abdellaoui A., Byrne EM, Esko T., de Geus EJ, Hemani G., Hottenga JJ, Kloiber S., Levinson DF, Lucae S., Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium(Corporate Collaborator), Martin NG, Medland SE, Metspalu A., Milani L., Noethen MM, Potash JB, Rietschel M., et al. Molecular psychiatry, 2015/06/01, Volume 20, Issue 6, p.735-43, (2015) Read More / View Supplemental Materials
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Characterization of bipolar disorder patient-specific induced pluripotent stem cells from a family reveals neurodevelopmental and mRNA expression abnormalities.Madison, JM, Zhou F., Nigam A., Hussain A., Barker DD, Nehme R., van der Ven K., Hsu J., Wolf P., Fleishman M., O'Dushlaine C., Rose S., Chambert K., Lau FH, Ahfeldt T., Rueckert EH, Sheridan SD, Fass DM, Nemesh J., Mullen TE, et al. Molecular psychiatry, 2015/06/01, Volume 20, Issue 6, p.703-17, (2015) Read More / View Supplemental Materials
Abstract
Genetic absence of PD-1 promotes accumulation of terminally differentiated exhausted CD8+ T cells.Odorizzi, PM, Pauken KE, Paley MA, Sharpe A., and Wherry EJ The Journal of experimental medicine, 2015/06/01, (2015) Read More / View Supplemental Materials
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