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Submitted
Synthesis, cellular evaluation and mechanism-of-action of piperlongumine analogsAdams, DJ, Dai M., Pellegrino G., Wagner BK, Stern AM, Shamji AF, and Schreiber SL, (Submitted) Read More / View Supplemental Materials
2015
Gender Disparity and Mutation Burden in Metastatic Melanoma.Gupta, S., Artomov M., Goggins W., Daly M., and Tsao H. Journal of the National Cancer Institute, 2015/11/01, Volume 107, Issue 11, (2015) Read More / View Supplemental Materials
Abstract
Epidemiologic Investigation of a Cluster of Neuroinvasive Bacillus cereus Infections in 5 Patients With Acute Myelogenous Leukemia.Rhee, C., Klompas M., Tamburini FB, Fremin BJ, Chea N., Epstein L., Halpin AL, Guh A., Gallen R., Coulliette A., Gee J., Hsieh C., Desjardins CA, Pedamullu CS, DeAngelo DJ, Manzo VE, Folkerth RD, Milner DA Jr, Pecora N., Osborne M., et al. Open forum infectious diseases, 2015/09/01, Volume 2, Issue 3, p.ofv096, (2015) Read More / View Supplemental Materials
Abstract
Genome Evolution and Innovation across the Four Major Lineages of Cryptococcus gattii.Farrer, RA, Desjardins CA, Sakthikumar S., Gujja S., Saif S., Zeng Q., Chen Y., Voelz K., Heitman J., May RC, Fisher MC, and Cuomo CA mBio, 2015/09/01, Volume 6, Issue 5, (2015) Read More / View Supplemental Materials
Abstract
High loading of polygenic risk in cases with chronic schizophrenia.Meier, SM, Agerbo E., Maier R., Pedersen CB, Lang M., Grove J., Hollegaard MV, Demontis D., Trabjerg BB, Hjorthøj C., Ripke S., Degenhardt F., Nöthen MM, Rujescu D., Maier W., MooDS SCZ Consortium, Werge T., Mors O., Hougaard DM, Børglum AD, et al. Molecular psychiatry, 2015/09/01, (2015) Read More / View Supplemental Materials
Abstract
The molecular era of the mitochondrial calcium uniporter.Kamer, KJ, and Mootha VK Nature reviews. Molecular cell biology, 2015/09/01, Volume 16, Issue 9, p.545-53, (2015) Read More / View Supplemental Materials
Abstract
Genetic variance estimation with imputed variants finds negligible missing heritability for human height and body mass index.Yang, J., Bakshi A., Zhu Z., Hemani G., Vinkhuyzen AA, Lee SH, Robinson MR, Perry JR, Nolte IM, van Vliet-Ostaptchouk JV, Snieder H., study LifeLines Cohort, Esko T., Milani L., Mägi R., Metspalu A., Hamsten A., Magnusson PK, Pedersen NL, Ingelsson E., et al. Nature genetics, 2015/08/31, (2015) Read More / View Supplemental Materials
Abstract
The Genetics of Stress-Related Disorders: PTSD, Depression and Anxiety Disorders.Smoller, JW Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015/08/31, (2015) Read More / View Supplemental Materials
Abstract
Sequence Analysis and Characterization of Active Human Alu subfamilies Based on the 1000 Genomes Pilot Project.Konkel, MK, Walker JA, Hotard AB, Ranck MC, Fontenot CC, Storer J., Stewart C., Marth GT, 1000 Genomes Consortium, and Batzer MA Genome biology and evolution, 2015/08/29, (2015) Read More / View Supplemental Materials
Abstract
Chemical perturbation of an intrinsically disordered region of TFIID distinguishes two modes of transcription initiation.Zhang, Z., Boskovic Z., Hussain MM, Hu W., Inouye C., Kim HJ, Abole AK, Doud MK, Lewis TA, Koehler AN, Schreiber SL, and Tjian R. eLife, 2015/08/28, Volume 4, (2015) Read More / View Supplemental Materials
Abstract
EHMT1 and EHMT2 inhibition induce fetal hemoglobin expression.Renneville, A., van Galen P., Canver MC, McConkey M., Krill-Burger JM, Dorfman DM, Holson EB, Bernstein BE, Orkin SH, Bauer DE, and Ebert BL Blood, 2015/08/28, (2015) Read More / View Supplemental Materials
Abstract
Ethnically shared and heterogeneous impacts of molecular pathways suggested by the genome-wide meta-analysis of rheumatoid arthritis.Okada, Y., Raj T., and Yamamoto K. Rheumatology (Oxford, England), 2015/08/28, (2015) Read More / View Supplemental Materials
Transgenic labeling of parvalbumin-expressing neurons with tdTomato.Kaiser, T., Ting JT, Monteiro P., and Feng G. Neuroscience, 2015/08/28, (2015) Read More / View Supplemental Materials
Abstract
Crystal Structure of Staphylococcus aureus Cas9.Nishimasu, H., Cong L., Yan WX, Ran FA, Zetsche B., Li Y., Kurabayashi A., Ishitani R., Zhang F., and Nureki O. Cell, 2015/08/27, Volume 162, Issue 5, p.1113-26, (2015) Read More / View Supplemental Materials
Abstract
Small-Molecule Reactivation of Mutant p53 to Wild-Type-like p53 through the p53-Hsp40 Regulatory Axis.Hiraki, M., Hwang SY, Cao S., Ramadhar TR, Byun S., Yoon KW, Lee JH, Chu K., Gurkar AU, Kolev V., Zhang J., Namba T., Murphy ME, Newman DJ, Mandinova A., Clardy J., and Lee SW Chemistry & biology, 2015/08/27, (2015) Read More / View Supplemental Materials
Abstract
Fusobacterium nucleatum in colorectal carcinoma tissue and patient prognosis.Mima, K., Nishihara R., Qian ZR, Cao Y., Sukawa Y., Nowak JA, Yang J., Dou R., Masugi Y., Song M., Kostic AD, Giannakis M., Bullman S., Milner DA, Baba H., Giovannucci EL, Garraway LA, Freeman GJ, Dranoff G., Garrett WS, et al. Gut, 2015/08/26, (2015) Read More / View Supplemental Materials
Abstract
Genome-wide RNA-Seq of Human Motor Neurons Implicates Selective ER Stress Activation in Spinal Muscular Atrophy.Ng, SY, Soh BS, Rodriguez-Muela N., Hendrickson DG, Price F., Rinn JL, and Rubin LL Cell stem cell, 2015/08/26, (2015) Read More / View Supplemental Materials
Abstract
Sequence-Level Analysis of the Major European Huntington Disease Haplotype.Lee, JM, Kim KH, Shin A., Chao MJ, Abu Elneel K., Gillis T., Mysore JS, Kaye JA, Zahed H., Kratter IH, Daub AC, Finkbeiner S., Li H., Roach JC, Goodman N., Hood L., Myers RH, Macdonald ME, and Gusella JF American journal of human genetics, 2015/08/26, (2015) Read More / View Supplemental Materials
Abstract
Commissural functional topography of the inferior colliculus assessed in vitro.Lee, CC, Yanagawa Y., and Imaizumi K. Hearing research, 2015/08/25, (2015) Read More / View Supplemental Materials
Abstract
Comparative genomics of Fusarium oxysporum f. sp. melonis reveals the secreted protein recognized by the Fom-2 resistance gene in melon.Schmidt, SM, Lukasiewicz J., Farrer R., van Dam P., Bertoldo C., and Rep M. The New phytologist, 2015/08/25, (2015) Read More / View Supplemental Materials
Abstract
Genetic association analyses highlight biological pathways underlying mitral valve prolapse.Dina, C., Bouatia-Naji N., Tucker N., Delling FN, Toomer K., Durst R., Perrocheau M., Fernandez-Friera L., Solis J., investigators PROMESA, Le Tourneau T., Chen MH, Probst V., Bosse Y., Pibarot P., Zelenika D., Lathrop M., Hercberg S., Roussel R., Benjamin EJ, et al. Nature genetics, 2015/08/24, (2015) Read More / View Supplemental Materials
Abstract
In situ single-cell analysis identifies heterogeneity for PIK3CA mutation and HER2 amplification in HER2-positive breast cancer.Janiszewska, M., Liu L., Almendro V., Kuang Y., Paweletz C., Sakr RA, Weigelt B., Hanker AB, Chandarlapaty S., King TA, Reis-Filho JS, Arteaga CL, Park SY, Michor F., and Polyak K. Nature genetics, 2015/08/24, (2015) Read More / View Supplemental Materials
Abstract
A direct fate exclusion mechanism by Sonic hedgehog-regulated transcriptional repressors.Nishi, Y., Zhang X., Jeong J., Peterson KA, Vedenko A., Bulyk ML, Hide WA, and McMahon AP Development (Cambridge, England), 2015/08/20, (2015) Read More / View Supplemental Materials
Abstract
Mutations in PIGY: expanding the phenotype of inherited glycosylphosphatidylinositol (GPI) deficiencies.Ilkovski, B., Pagnamenta AT, O'Grady GL, Kinoshita T., Howard MF, Lek M., Thomas B., Turner A., Christodoulou J., Sillence D., Knight SJ, Popitsch N., Keays DA, Anzilotti C., Goriely A., Waddell LB, Brilot F., North KN, Kanzawa N., Macarthur DG, et al. Human molecular genetics, 2015/08/20, (2015) Read More / View Supplemental Materials
Abstract
Disruption of the Rag-Ragulator Complex by c17orf59 Inhibits mTORC1.Schweitzer, LD, Comb WC, Bar-Peled L., and Sabatini DM Cell reports, 2015/08/19, (2015) Read More / View Supplemental Materials
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FTO Obesity Variant Circuitry and Adipocyte Browning in Humans.Claussnitzer, M., Dankel SN, Kim KH, Quon G., Meuleman W., Haugen C., Glunk V., Sousa IS, Beaudry JL, Puviindran V., Abdennur NA, Liu J., Svensson PA, Hsu YH, Drucker DJ, Mellgren G., Hui CC, Hauner H., and Kellis M. The New England journal of medicine, 2015/08/19, (2015) Read More / View Supplemental Materials
Abstract
PRC2 Is Required to Maintain Expression of the Maternal Gtl2-Rian-Mirg Locus by Preventing De Novo DNA Methylation in Mouse Embryonic Stem Cells.Das, PP, Hendrix DA, Apostolou E., Buchner AH, Canver MC, Beyaz S., Ljuboja D., Kuintzle R., Kim W., Karnik R., Shao Z., Xie H., Xu J., De Los Angeles A., Zhang Y., Choe J., Jun DL, Shen X., Gregory RI, Daley GQ, et al. Cell reports, 2015/08/19, (2015) Read More / View Supplemental Materials
Abstract
Association studies of genomic variants with treatment response to risperidone, clozapine, quetiapine and chlorpromazine in the Chinese Han population.Xu, Q., Wu X., Li M., Huang H., Minica C., Yi Z., Wang G., Shen L., Xing Q., Shi Y., He L., and Qin S. The pharmacogenomics journal, 2015/08/18, (2015) Read More / View Supplemental Materials
Abstract
Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations.Hayes, MG, Urbanek M., Ehrmann DA, Armstrong LL, Lee JY, Sisk R., Karaderi T., Barber TM, McCarthy MI, Franks S., Lindgren CM, Welt CK, Diamanti-Kandarakis E., Panidis D., Goodarzi MO, Azziz R., Zhang Y., James RG, Olivier M., Kissebah AH, et al. Nature communications, 2015/08/18, Volume 6, p.7502, (2015) Read More / View Supplemental Materials
Abstract
New data and an old puzzle: the negative association between schizophrenia and rheumatoid arthritis.Lee, SH, Byrne EM, Hultman CM, Kähler A., Vinkhuyzen AA, Ripke S., Andreassen OA, Frisell T., Gusev A., Hu X., Karlsson R., Mantzioris VX, McGrath JJ, Mehta D., Stahl EA, Zhao Q., Kendler KS, Sullivan PF, Price AL, O'Donovan M., et al. International journal of epidemiology, 2015/08/18, (2015) Read More / View Supplemental Materials
Abstract
Systematic chromatin state comparison of epigenomes associated with diverse properties including sex and tissue type.Yen, A., and Kellis M. Nature communications, 2015/08/18, Volume 6, p.7973, (2015) Read More / View Supplemental Materials
Abstract
Clinical Effects of Phosphodiesterase 3A Mutations in Inherited Hypertension With Brachydactyly.Toka, O., Tank J., Schächterle C., Aydin A., Maass PG, Elitok S., Bartels-Klein E., Hollfinger I., Lindschau C., Mai K., Boschmann M., Rahn G., Movsesian MA, Müller T., Doescher A., Gnoth S., Mühl A., Toka HR, Wefeld-Neuenfeld Y., Utz W., et al. Hypertension, 2015/08/17, (2015) Read More / View Supplemental Materials
Abstract
Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6.Park, E., Kim N., Ficarro SB, Zhang Y., Lee BI, Cho A., Kim K., Park AK, Park WY, Murray B., Meyerson M., Beroukhim R., Marto JA, Cho J., and Eck MJ Nature structural & molecular biology, 2015/08/17, (2015) Read More / View Supplemental Materials
Abstract
Doxycycline: new tricks for an old drug.Barbie, DA, and Kennedy BK Oncotarget, 2015/08/14, Volume 6, Issue 23, p.19336-7, (2015) Read More / View Supplemental Materials
Clinical Sequencing Uncovers Origins and Evolution of Lassa Virus.Andersen, KG, Shapiro BJ, Matranga CB, Sealfon R., Lin AE, Moses LM, Folarin OA, Goba A., Odia I., Ehiane PE, Momoh M., England EM, Winnicki S., Branco LM, Gire SK, Phelan E., Tariyal R., Tewhey R., Omoniwa O., Fullah M., et al. Cell, 2015/08/13, Volume 162, Issue 4, p.738-50, (2015) Read More / View Supplemental Materials
Abstract
Individual intestinal symbionts induce a distinct population of RORγ+ regulatory T cells.Sefik, E., Geva-Zatorsky N., Oh S., Konnikova L., Zemmour D., McGuire AM, Burzyn D., Ortiz-Lopez A., Lobera M., Yang J., Ghosh S., Earl A., Snapper SB, Jupp R., Kasper D., Mathis D., and Benoist C. Science (New York, N.Y.), 2015/08/13, (2015) Read More / View Supplemental Materials
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Korean Atrial Fibrillation (AF) Network: Genetic Variants for AF Do Not Predict Ablation Success.Choi, EK, Park JH, Lee JY, Nam CM, Hwang MK, Uhm JS, Joung B., Ko YG, Lee MH, Lubitz SA, Ellinor PT, and Pak HN Journal of the American Heart Association, 2015/08/13, Volume 4, Issue 8, (2015) Read More / View Supplemental Materials
Abstract
GWAS of longitudinal amyloid accumulation on 18F-florbetapir PET in Alzheimer's disease implicates microglial activation gene IL1RAP.Ramanan, VK, Risacher SL, Nho K., Kim S., Shen L., McDonald BC, Yoder KK, Hutchins GD, West JD, Tallman EF, Gao S., Foroud TM, Farlow MR, De Jager PL, Bennett DA, Aisen PS, Petersen RC, Jack CR Jr, Toga AW, Green RC, et al. Brain : a journal of neurology, 2015/08/11, (2015) Read More / View Supplemental Materials
Abstract
Heavier smoking may lead to a relative increase in waist circumference: evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium.Morris, RW, Taylor AE, Fluharty ME, Bjørngaard JH, Åsvold BO, Elvestad Gabrielsen M., Campbell A., Marioni R., Kumari M., Korhonen T., Männistö S., Marques-Vidal P., Kaakinen M., Cavadino A., Postmus I., Husemoen LL, Skaaby T., Ahluwalia TV, Treur JL, Willemsen G., et al. BMJ open, 2015/08/11, Volume 5, Issue 8, p.e008808, (2015) Read More / View Supplemental Materials
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Adaptive evolution of malaria parasites in French Guiana: Reversal of chloroquine resistance by acquisition of a mutation in pfcrt.Pelleau, S., Moss EL, Dhingra SK, Volney B., Casteras J., Gabryszewski SJ, Volkman SK, Wirth DF, Legrand E., Fidock DA, Neafsey DE, and Musset L. Proceedings of the National Academy of Sciences of the United States of America, 2015/08/10, (2015) Read More / View Supplemental Materials
Abstract
An APOBEC3A hypermutation signature is distinguishable from the signature of background mutagenesis by APOBEC3B in human cancers.Chan, K., Roberts SA, Klimczak LJ, Sterling JF, Saini N., Malc EP, Kim J., Kwiatkowski DJ, Fargo DC, Mieczkowski PA, Getz G., and Gordenin DA Nature genetics, 2015/08/10, (2015) Read More / View Supplemental Materials
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Malaria Molecular Epidemiology: Lessons from the International Centers of Excellence for Malaria Research Network.Escalante, AA, Ferreira MU, Vinetz JM, Volkman SK, Cui L., Gamboa D., Krogstad DJ, Barry AE, Carlton JM, van Eijk AM, Pradhan K., Mueller I., Greenhouse B., Pacheco MA, Vallejo AF, Herrera S., and Felger I. The American journal of tropical medicine and hygiene, 2015/08/10, (2015) Read More / View Supplemental Materials
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Population Genetics, Evolutionary Genomics, and Genome-Wide Studies of Malaria: A View Across the International Centers of Excellence for Malaria Research.Carlton, JM, Volkman SK, Uplekar S., Hupalo DN, Pereira Alves JM, Cui L., Donnelly M., Roos DS, Harb OS, Acosta M., Read A., Ribolla PE, Singh OP, Valecha N., Wassmer SC, Ferreira M., and Escalante AA The American journal of tropical medicine and hygiene, 2015/08/10, (2015) Read More / View Supplemental Materials
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Widespread non-additive and interaction effects within HLA loci modulate the risk of autoimmune diseases.Lenz, TL, Deutsch AJ, Han B., Hu X., Okada Y., Eyre S., Knapp M., Zhernakova A., Huizinga TW, Abecasis G., Becker J., Boeckxstaens GE, Chen WM, Franke A., Gladman DD, Gockel I., Gutierrez-Achury J., Martin J., Nair RP, Nöthen MM, et al. Nature genetics, 2015/08/10, (2015) Read More / View Supplemental Materials
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Genetic predisposition to weight loss & regain with lifestyle intervention: analyses from the Diabetes Prevention Program & the Look AHEAD randomized controlled trials.Papandonatos, GD, Pan Q., Pajewski NM, Delahanty LM, Peter I., Erar B., Ahmad S., Harden M., Chen L., Fontanillas P., GIANT Consortium, Wagenknecht LE, Kahn SE, Wing RR, Jablonski KA, Huggins GS, Knowler WC, Florez JC, McCaffery JM, Franks PW, et al. Diabetes, 2015/08/07, (2015) Read More / View Supplemental Materials
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A Dominant Mutation in Human RAD51 Reveals Its Function in DNA Interstrand Crosslink Repair Independent of Homologous Recombination.Wang, AT, Kim T., Wagner JE, Conti BA, Lach FP, Huang AL, Molina H., Sanborn EM, Zierhut H., Cornes BK, Abhyankar A., Sougnez C., Gabriel SB, Auerbach AD, Kowalczykowski SC, and Smogorzewska A. Molecular cell, 2015/08/06, Volume 59, Issue 3, p.478-90, (2015) Read More / View Supplemental Materials
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Global diversity, population stratification, and selection of human copy number variation.Sudmant, PH, Mallick S., Nelson BJ, Hormozdiari F., Krumm N., Huddleston J., Coe BP, Baker C., Nordenfelt S., Bamshad M., Jorde LB, Posukh OL, Sahakyan H., Watkins WS, Yepiskoposyan L., Abdullah MS, Bravi CM, Capelli C., Hervig T., Wee JT, et al. Science (New York, N.Y.), 2015/08/06, (2015) Read More / View Supplemental Materials
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Rheumatoid factor is associated with the distribution of hand joint destruction in rheumatoid arthritis.Terao, C., Yamakawa N., Yano K., Markusse IM, Ikari K., Yoshida S., Furu M., Hashimoto M., Ito H., Fujii T., Ohmura K., Murakami K., Takahashi M., Hamaguchi M., Tabara Y., Taniguchi A., Momohara S., Raychaudhuri S., Allaart CF, Yamanaka H., et al. Arthritis & rheumatology (Hoboken, N.J.), 2015/08/05, (2015) Read More / View Supplemental Materials
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Dynamics of Tumor Heterogeneity Derived from Clonal Karyotypic Evolution.Laughney, AM, Elizalde S., Genovese G., and Bakhoum SF Cell reports, 2015/08/04, Volume 12, Issue 5, p.809-820, (2015) Read More / View Supplemental Materials
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Hypoxia-Mediated Increases in l-2-hydroxyglutarate Coordinate the Metabolic Response to Reductive Stress.Oldham, WM, Clish CB, Yang Y., and Loscalzo J. Cell metabolism, 2015/08/04, Volume 22, Issue 2, p.291-303, (2015) Read More / View Supplemental Materials
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Organization of the Mammalian Metabolome according to Organ Function, Lineage Specialization, and Longevity.Ma, S., Yim SH, Lee SG, Kim EB, Lee SR, Chang KT, Buffenstein R., Lewis KN, Park TJ, Miller RA, Clish CB, and Gladyshev VN Cell metabolism, 2015/08/04, Volume 22, Issue 2, p.332-43, (2015) Read More / View Supplemental Materials
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Preserved DNA Damage Checkpoint Pathway Protects against Complications in Long-Standing Type 1 Diabetes.Bhatt, S., Gupta MK, Khamaisi M., Martinez R., Gritsenko MA, Wagner BK, Guye P., Busskamp V., Shirakawa J., Wu G., Liew CW, Clauss TR, Valdez I., El Ouaamari A., Dirice E., Takatani T., Keenan HA, Smith RD, Church G., Weiss R., et al. Cell metabolism, 2015/08/04, Volume 22, Issue 2, p.239-52, (2015) Read More / View Supplemental Materials
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Rare coding variants and X-linked loci associated with age at menarche.Lunetta, KL, Day FR, Sulem P., Ruth KS, Tung JY, Hinds DA, Esko T., Elks CE, Altmaier E., He C., Huffman JE, Mihailov E., Porcu E., Robino A., Rose LM, Schick UM, Stolk L., Teumer A., Thompson DJ, Traglia M., et al. Nature communications, 2015/08/04, Volume 6, p.7756, (2015) Read More / View Supplemental Materials
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Rare variants in the notch signaling pathway describe a novel type of autosomal recessive Klippel-Feil syndrome.Karaca, E., Yuregir OO, Bozdogan ST, Aslan H., Pehlivan D., Jhangiani SN, Akdemir ZC, Gambin T., Bayram Y., Atik MM, Erdin S., Muzny D., Gibbs RA, Lupski JR, and Baylor-Hopkins Center for Mendelian Genomics American journal of medical genetics. Part A, 2015/08/04, (2015) Read More / View Supplemental Materials
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Automated, high-throughput derivation, characterization and differentiation of induced pluripotent stem cells.Paull, D., Sevilla A., Zhou H., Hahn AK, Im HK, Napolitano C., Tsankov A., Shang L., Krumholz K., Jagadeesan P., Woodard CM, Sun B., Vilboux T., Zimmer M., Forero E., Moroziewicz DN, Martinez H., Malicdan MC, Weiss KA, Vensand LB, et al. Nature methods, 2015/08/03, (2015) Read More / View Supplemental Materials
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Improved canine exome designs, featuring ncRNAs and increased coverage of protein coding genes.Broeckx, BJ, Hitte C., Coopman F., Verhoeven GE, De Keulenaer S., De Meester E., Derrien T., Alfoldi J., Lindblad-Toh K., Bosmans T., Gielen I., Van Bree H., Van Ryssen B., Saunders JH, Van Nieuwerburgh F., and Deforce D. Scientific reports, 2015/08/03, Volume 5, p.12810, (2015) Read More / View Supplemental Materials
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Dominance of Deleterious Alleles Controls the Response to a Population Bottleneck.Balick, DJ, Do R., Cassa CA, Reich D., and Sunyaev SR PLoS genetics, 2015/08/01, Volume 11, Issue 8, p.e1005436, (2015) Read More / View Supplemental Materials
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ERBB2 Emerges as a New Target for Colorectal Cancer.Pectasides, E., and Bass AJ Cancer discovery, 2015/08/01, Volume 5, Issue 8, p.799-801, (2015) Read More / View Supplemental Materials
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CELL DEATH. Control of signaling-mediated clearance of apoptotic cells by the tumor suppressor p53.Yoon, KW, Byun S., Kwon E., Hwang SY, Chu K., Hiraki M., Jo SH, Weins A., Hakroush S., Cebulla A., Sykes DB, Greka A., Mundel P., Fisher DE, Mandinova A., and Lee SW Science (New York, N.Y.), 2015/07/31, Volume 349, Issue 6247, p.1261669, (2015) Read More / View Supplemental Materials
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Exploring the 3-piperidin-4-yl-1H-indole scaffold as a novel antimalarial chemotype.Santos, SA, Lukens AK, Coelho L., Nogueira F., Wirth DF, Mazitschek R., Moreira R., and Paulo A. European journal of medicinal chemistry, 2015/07/31, Volume 102, p.320-333, (2015) Read More / View Supplemental Materials
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METABOLISM. S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction.Yang, L., Calay ES, Fan J., Arduini A., Kunz RC, Gygi SP, Yalcin A., Fu S., and Hotamisligil GS Science (New York, N.Y.), 2015/07/31, Volume 349, Issue 6247, p.500-6, (2015) Read More / View Supplemental Materials
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An Essential Role of the Mitochondrial Electron Transport Chain in Cell Proliferation Is to Enable Aspartate Synthesis.Birsoy, K., Wang T., Chen WW, Freinkman E., Abu-Remaileh M., and Sabatini DM Cell, 2015/07/30, Volume 162, Issue 3, p.540-51, (2015) Read More / View Supplemental Materials
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A Genome-wide CRISPR Screen in Primary Immune Cells to Dissect Regulatory Networks.Parnas, O., Jovanovic M., Eisenhaure TM, Herbst RH, Dixit A., Ye CJ, Przybylski D., Platt RJ, Tirosh I., Sanjana NE, Shalem O., Satija R., Raychowdhury R., Mertins P., Carr SA, Zhang F., Hacohen N., and Regev A. Cell, 2015/07/30, Volume 162, Issue 3, p.675-86, (2015) Read More / View Supplemental Materials
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Growth dynamics of gut microbiota in health and disease inferred from single metagenomic samples.Korem, T., Zeevi D., Suez J., Weinberger A., Avnit-Sagi T., Pompan-Lotan M., Matot E., Jona G., Harmelin A., Cohen N., Sirota-Madi A., Thaiss CA, Pevsner-Fischer M., Sorek R., Xavier R., Elinav E., and Segal E. Science (New York, N.Y.), 2015/07/30, (2015) Read More / View Supplemental Materials
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Ground State Conditions Induce Rapid Reorganization of Core Pluripotency Factor Binding before Global Epigenetic Reprogramming.Galonska, C., Ziller MJ, Karnik R., and Meissner A. Cell stem cell, 2015/07/29, (2015) Read More / View Supplemental Materials
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The Stress-Induced Atf3-Gelsolin Cascade Underlies Dendritic Spine Deficits in Neuronal Models of Tuberous Sclerosis Complex.Nie, D., Chen Z., Ebrahimi-Fakhari D., Di Nardo A., Julich K., Robson VK, Cheng YC, Woolf CJ, Heiman M., and Sahin M. The Journal of neuroscience : the official journal of the Society for Neuroscience, 2015/07/29, Volume 35, Issue 30, p.10762-72, (2015) Read More / View Supplemental Materials
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A targeted functional RNAi screen uncovers Glypican 5 as an entry factor for hepatitis B and D viruses.Verrier, ER, Colpitts CC, Bach C., Heydmann L., Weiss A., Renaud M., Durand SC, Habersetzer F., Durantel D., Abou-Jaoudé G., López Ledesma MM, Felmlee DJ, Soumillon M., Croonenborghs T., Pochet N., Nassal M., Schuster C., Brino L., Sureau C., Zeisel MB, et al. Hepatology (Baltimore, Md.), 2015/07/29, (2015) Read More / View Supplemental Materials
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FermiKit: assembly-based variant calling for Illumina resequencing data.Li, H. Bioinformatics (Oxford, England), 2015/07/27, (2015) Read More / View Supplemental Materials
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CXCR3 Polymorphism and Expression Associate with Spontaneous Preterm Birth.Karjalainen, MK, Ojaniemi M., Haapalainen AM, Mahlman M., Salminen A., Huusko JM, Määttä TA, Kaukola T., Anttonen J., Ulvila J., Haataja R., Teramo K., Kingsmore SF, Palotie A., Muglia LJ, Rämet M., and Hallman M. Journal of immunology (Baltimore, Md. : 1950), 2015/07/24, (2015) Read More / View Supplemental Materials
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Multiple cell and population-level interactions with mouse embryonic stem cell heterogeneity.Cannon, D., Corrigan AM, Miermont A., McDonel P., and Chubb JR Development (Cambridge, England), 2015/07/24, (2015) Read More / View Supplemental Materials
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Genotype-specific variation in West Nile virus dispersal in California.Duggal, NK, Reisen WK, Fang Y., Newman RM, Yang X., Ebel GD, and Brault AC Virology, 2015/07/23, Volume 485, p.79-85, (2015) Read More / View Supplemental Materials
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Protein Crowding Is a Determinant of Lipid Droplet Protein Composition.Kory, N., Thiam AR, Farese RV Jr, and Walther TC Developmental cell, 2015/07/22, (2015) Read More / View Supplemental Materials
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Steroid sex hormones, sex hormone binding globulin and diabetes incidence in the Diabetes Prevention Program.Mather, KM, Kim C., Christophi CA, Aroda VR, Knowler WC, Edelstein SE, Florez JC, Labrie F., Kahn SE, Goldberg RB, Barrett-Connor E., and Diabetes Prevention Program Research Group The Journal of clinical endocrinology and metabolism, 2015/07/22, p.jc20152328, (2015) Read More / View Supplemental Materials
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Analysis of exome sequence in 604 trios for recessive genotypes in schizophrenia.Rees, E., Kirov G., Walters JT, Richards AL, Howrigan D., Kavanagh DH, Pocklington AJ, Fromer M., Ruderfer DM, Georgieva L., Carrera N., Gormley P., Palta P., Williams H., Dwyer S., Johnson JS, Roussos P., Barker DD, Banks E., Milanova V., et al. Translational psychiatry, 2015/07/21, Volume 5, p.e607, (2015) Read More / View Supplemental Materials
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Functional genomics identifies negative regulatory nodes controlling phagocyte oxidative burst.Graham, DB, Becker CE, Doan A., Goel G., Villablanca EJ, Knights D., Mok A., Ng AC, Doench JG, Root DE, Clish CB, and Xavier RJ Nature communications, 2015/07/21, Volume 6, p.7838, (2015) Read More / View Supplemental Materials
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Genetic evidence for two founding populations of the Americas.Skoglund, P., Mallick S., Bortolini MC, Chennagiri N., Hünemeier T., Petzl-Erler ML, Salzano FM, Patterson N., and Reich D. Nature, 2015/07/21, (2015) Read More / View Supplemental Materials
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The promise and peril of chemical probes.Arrowsmith, CH, Audia JE, Austin C., Baell J., Bennett J., Blagg J., Bountra C., Brennan PE, Brown PJ, Bunnage ME, Buser-Doepner C., Campbell RM, Carter AJ, Cohen P., Copeland RA, Cravatt B., Dahlin JL, Dhanak D., Edwards AM, Frye SV, et al. Nature chemical biology, 2015/07/21, Volume 11, Issue 8, p.536-41, (2015) Read More / View Supplemental Materials
A genetic basis of variation in eccrine sweat gland and hair follicle density.Kamberov, YG, Karlsson EK, Kamberova GL, Lieberman DE, Sabeti PC, Morgan BA, and Tabin CJ Proceedings of the National Academy of Sciences of the United States of America, 2015/07/20, (2015) Read More / View Supplemental Materials
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Paired exome analysis of Barrett's esophagus and adenocarcinoma.Stachler, MD, Taylor-Weiner A., Peng S., McKenna A., Loda M., Stewart C., Stojanov P., Seepo S., Lawrence MS, Lin J., Chang AC, Gabriel SB, Lander E. S., Beer DG, Getz G., Carter SL, and Bass AJ Nature genetics, 2015/07/20, (2015) Read More / View Supplemental Materials
Abstract
Small-molecule enhancers of autophagy modulate cellular disease phenotypes suggested by human genetics.Kuo, SY, Castoreno AB, Aldrich LN, Lassen KG, Goel G., Dančík V., Kuballa P., Latorre I., Conway KL, Sarkar S., Maetzel D., Jaenisch R., Clemons PA, Schreiber SL, Shamji AF, and Xavier RJ Proceedings of the National Academy of Sciences of the United States of America, 2015/07/20, (2015) Read More / View Supplemental Materials
Abstract
GenomeConnect: Matchmaking Between Patients, Clinical Laboratories and Researchers to Improve Genomic Knowledge.Kirkpatrick, BE, Riggs ER, Azzariti DR, Miller VR, Ledbetter DH, Miller DT, Rehm H., Martin CL, Faucett WA, and ClinGen Resource Human mutation, 2015/07/16, (2015) Read More / View Supplemental Materials
Abstract
Integrative Analyses of Human Reprogramming Reveal Dynamic Nature of Induced Pluripotency.Cacchiarelli, D., Trapnell C., Ziller MJ, Soumillon M., Cesana M., Karnik R., Donaghey J., Smith ZD, Ratanasirintrawoot S., Zhang X., Ho Sui SJ, Wu Z., Akopian V., Gifford CA, Doench J., Rinn JL, Daley GQ, Meissner A., Lander E. S., and Mikkelsen TS Cell, 2015/07/16, Volume 162, Issue 2, p.412-24, (2015) Read More / View Supplemental Materials
Abstract
Revisited HLA and non-HLA genetics of Takayasu arteritis-where are we?Terao, C. Journal of human genetics, 2015/07/16, (2015) Read More / View Supplemental Materials
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Body Mass Index, Genetic Susceptibility, and Risk of Complications Among Individuals with Crohn's Disease.Pringle, PL, Stewart KO, Peloquin JM, Sturgeon HC, Nguyen D., Sauk J., Garber JJ, Yajnik V., Ananthakrishnan AN, Chan AT, Xavier RJ, and Khalili H. Inflammatory bowel diseases, 2015/07/15, (2015) Read More / View Supplemental Materials
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Chromerid genomes reveal the evolutionary path from photosynthetic algae to obligate intracellular parasites.Woo, YH, Ansari H., Otto TD, Klinger CM, Kolisko M., Michálek J., Saxena A., Shanmugam D., Tayyrov A., Veluchamy A., Ali S., Bernal A., Del Campo J., Cihlář J., Flegontov P., Gornik SG, Hajdušková E., Horák A., Janouškovec J., Katris NJ, et al. eLife, 2015/07/15, Volume 4, (2015) Read More / View Supplemental Materials
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Extending the phenotypic spectrum of RBFOX1 deletions: Sporadic focal epilepsy.Lal, D., Pernhorst K., Klein KM, Reif P., Tozzi R., Toliat MR, Winterer G., Neubauer B., Nürnberg P., Rosenow F., Becker F., Lerche H., Kunz WS, Kurki MI, Hoffmann P., Becker AJ, Perucca E., Zara F., Sander T., and Weber YG Epilepsia, 2015/07/15, (2015) Read More / View Supplemental Materials
Abstract
CCL2 Promotes Colorectal Carcinogenesis by Enhancing Polymorphonuclear Myeloid-Derived Suppressor Cell Population and Function.Chun, E., Lavoie S., Michaud M., Gallini CA, Kim J., Soucy G., Odze R., Glickman JN, and Garrett WS Cell reports, 2015/07/14, Volume 12, Issue 2, p.244-257, (2015) Read More / View Supplemental Materials
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Near universal detection of alterations in CTNNB1 and Wnt pathway regulators in desmoid-type fibromatosis by whole-exome sequencing and genomic analysis.Crago, AM, Chmielecki J., Rosenberg M., O'Connor R., Byrne C., Wilder FG, Thorn K., Agius P., Kuk D., Socci ND, Qin LX, Meyerson M., Hameed M., and Singer S. Genes, chromosomes & cancer, 2015/07/14, (2015) Read More / View Supplemental Materials
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Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial Type II topoisomerases.Basarab, GS, Kern GH, McNulty J., Mueller JP, Lawrence K., Vishwanathan K., Alm RA, Barvian K., Doig P., Galullo V., Gardner H., Gowravaram M., Huband M., Kimzey A., Morningstar M., Kutschke A., Lahiri SD, Perros M., Singh R., Schuck VJ, et al. Scientific reports, 2015/07/14, Volume 5, p.11827, (2015) Read More / View Supplemental Materials
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Activity of the Type II JAK2 Inhibitor CHZ868 in B Cell Acute Lymphoblastic Leukemia.Wu, SC, Li LS, Kopp N., Montero J., Chapuy B., Yoda A., Christie AL, Liu H., Christodoulou A., van Bodegom D., van der Zwet J., Layer JV, Tivey T., Lane AA, Ryan JA, Ng SY, DeAngelo DJ, Stone RM, Steensma D., Wadleigh M., et al. Cancer cell, 2015/07/13, Volume 28, Issue 1, p.29-41, (2015) Read More / View Supplemental Materials
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Additive and interaction effects at three amino acid positions in HLA-DQ and HLA-DR molecules drive type 1 diabetes risk.Hu, X., Deutsch AJ, Lenz TL, Onengut-Gumuscu S., Han B., Chen WM, Howson JM, Todd JA, de Bakker PI, Rich SS, and Raychaudhuri S. Nature genetics, 2015/07/13, (2015) Read More / View Supplemental Materials
Abstract
Role of Autophagy in the Maintenance of Intestinal Homeostasis.Baxt, LA, and Xavier RJ Gastroenterology, 2015/07/10, (2015) Read More / View Supplemental Materials
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Association of Polymerase e-Mutated and Microsatellite-Instable Endometrial Cancers With Neoantigen Load, Number of Tumor-Infiltrating Lymphocytes, and Expression of PD-1 and PD-L1.Howitt, BE, Shukla SA, Sholl LM, Ritterhouse LL, Watkins JC, Rodig S., Stover E., Strickland KC, D'Andrea AD, Wu CJ, Matulonis UA, and Konstantinopoulos PA JAMA oncology, 2015/07/09, (2015) Read More / View Supplemental Materials
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Data analysis: Create a cloud commons.Stein, LD, Knoppers BM, Campbell P., Getz G., and Korbel JO Nature, 2015/07/09, Volume 523, Issue 7559, p.149-51, (2015) Read More / View Supplemental Materials
Lenalidomide induces ubiquitination and degradation of CK1α in del(5q) MDS.Krönke, J., Fink EC, Hollenbach PW, MacBeth KJ, Hurst SN, Udeshi ND, Chamberlain PP, Mani D. R., Man HW, Gandhi AK, Svinkina T., Schneider RK, McConkey M., Järås M., Griffiths E., Wetzler M., Bullinger L., Cathers BE, Carr SA, Chopra R., et al. Nature, 2015/07/09, Volume 523, Issue 7559, p.183-8, (2015) Read More / View Supplemental Materials
Abstract
Cross-sectional examination of metabolites and metabolic phenotypes in uremia.Kalim, S., Clish CB, Deferio JJ, Ortiz G., Moffet AS, Gerszten RE, Thadhani R., and Rhee EP BMC nephrology, 2015/07/07, Volume 16, p.98, (2015) Read More / View Supplemental Materials
Abstract
Deficiency of UBE2T, the E2 Ubiquitin Ligase Necessary for FANCD2 and FANCI Ubiquitination, Causes FA-T Subtype of Fanconi Anemia.Rickman, KA, Lach FP, Abhyankar A., Donovan FX, Sanborn EM, Kennedy JA, Sougnez C., Gabriel SB, Elemento O., Chandrasekharappa SC, Schindler D., Auerbach AD, and Smogorzewska A. Cell reports, 2015/07/07, Volume 12, Issue 1, p.35-41, (2015) Read More / View Supplemental Materials
Abstract
The Extracellular Matrix: Tools and Insights for the "Omics" Era.Naba, A., Clauser KR, Ding H., Whittaker CA, Carr SA, and Hynes R. O. Matrix biology : journal of the International Society for Matrix Biology, 2015/07/07, (2015) Read More / View Supplemental Materials
Abstract
Quantitative proteomics suggests decrease in the secretogranin-1 cerebrospinal fluid levels during the disease course of multiple sclerosis.Kroksveen, AC, Jaffe JD, Aasebø E., Barsnes H., Bjørlykke Y., Franciotta D., Keshishian H., Myhr KM, Opsahl JA, van Pesch V., Teunissen CE, Torkildsen Ø., Ulvik RJ, Vethe H., Carr SA, and Berven FS Proteomics, 2015/07/07, (2015) Read More / View Supplemental Materials
Abstract
Genome-Scale Protein Microarray Comparison of Human Antibody Responses in Plasmodium vivax Relapse and Reinfection.Chuquiyauri, R., Molina DM, Moss EL, Wang R., Gardner MJ, Brouwer KC, Torres S., Gilman RH, Llanos-Cuentas A., Neafsey DE, Felgner P., Liang X., and Vinetz JM The American journal of tropical medicine and hygiene, 2015/07/06, (2015) Read More / View Supplemental Materials
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