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2015
Rare coding variants and X-linked loci associated with age at menarche.Lunetta, KL, Day FR, Sulem P., Ruth KS, Tung JY, Hinds DA, Esko T., Elks CE, Altmaier E., He C., Huffman JE, Mihailov E., Porcu E., Robino A., Rose LM, Schick UM, Stolk L., Teumer A., Thompson DJ, Traglia M., et al. Nature communications, 2015/08/04, Volume 6, p.7756, (2015) Read More / View Supplemental Materials
Abstract
Directional dominance on stature and cognition in diverse human populations.Joshi, PK, Esko T., Mattsson H., Eklund N., Gandin I., Nutile T., Jackson AU, Schurmann C., Smith AV, Zhang W., Okada Y., Stančáková A., Faul JD, Zhao W., Bartz TM, Concas MP, Franceschini N., Enroth S., Vitart V., Trompet S., et al. Nature, 2015/07/01, (2015) Read More / View Supplemental Materials
Abstract
Discovery and Fine-Mapping of Glycaemic and Obesity-Related Trait Loci Using High-Density Imputation.Horikoshi, M., Mӓgi R., van de Bunt M., Surakka I., Sarin AP, Mahajan A., Marullo L., Thorleifsson G., Hӓgg S., Hottenga JJ, Ladenvall C., Ried JS, Winkler TW, Willems SM, Pervjakova N., Esko T., Beekman M., Nelson CP, Willenborg C., Wiltshire S., et al. PLoS genetics, 2015/07/01, Volume 11, Issue 7, p.e1005230, (2015) Read More / View Supplemental Materials
Abstract
Structural forms of the human amylase locus and their relationships to SNPs, haplotypes and obesity.Usher, CL, Handsaker RE, Esko T., Tuke MA, Weedon MN, Hastie AR, Cao H., Moon JE, Kashin S., Fuchsberger C., Metspalu A., Pato CN, Pato MT, McCarthy MI, Boehnke M., Altshuler DM, Frayling TM, Hirschhorn JN, and McCarroll SA Nature genetics, 2015/06/22, (2015) Read More / View Supplemental Materials
Abstract
Genome-wide association study identifies novel genetic variants contributing to variation in blood metabolite levels.Draisma, HH, Pool R., Kobl M., Jansen R., Petersen AK, Vaarhorst AA, Yet I., Haller T., Demirkan A., Esko T., Zhu G., Böhringer S., Beekman M., van Klinken JB, Römisch-Margl W., Prehn C., Adamski J., de Craen AJ, van Leeuwen EM, Amin N., et al. Nature communications, 2015/06/12, Volume 6, p.7208, (2015) Read More / View Supplemental Materials
Abstract
The association between lower educational attainment and depression owing to shared genetic effects? Results in ~25,000 subjects.Peyrot, WJ, Lee SH, Milaneschi Y., Abdellaoui A., Byrne EM, Esko T., de Geus EJ, Hemani G., Hottenga JJ, Kloiber S., Levinson DF, Lucae S., Major Depressive Disorder Working Group of the Psychiatric GWAS Consortium(Corporate Collaborator), Martin NG, Medland SE, Metspalu A., Milani L., Noethen MM, Potash JB, Rietschel M., et al. Molecular psychiatry, 2015/06/01, Volume 20, Issue 6, p.735-43, (2015) Read More / View Supplemental Materials
Abstract
Adiposity as a cause of cardiovascular disease: a Mendelian randomization study.Hägg, S., Fall T., Ploner A., Mägi R., Fischer K., Draisma HH, Kals M., de Vries PS, Dehghan A., Willems SM, Sarin AP, Kristiansson K., Nuotio ML, Havulinna AS, de Bruijn RF, Ikram MA, Kuningas M., Stricker BH, Franco OH, Benyamin B., et al. International journal of epidemiology, 2015/05/27, (2015) Read More / View Supplemental Materials
Abstract
Mendelian randomization study of height and risk of colorectal cancer.Thrift, AP, Gong J., Peters U., Chang-Claude J., Rudolph A., Slattery ML, Chan AT, Esko T., Wood AR, Yang J., Vedantam S., Gustafsson S., Pers TH, GIANT Consortium, Baron JA, Bezieau S., Küry S., Ogino S., Berndt SI, Casey G., et al. International journal of epidemiology, 2015/05/20, (2015) Read More / View Supplemental Materials
Abstract
The impact of low-frequency and rare variants on lipid levels.Surakka, I., Horikoshi M., Mägi R., Sarin AP, Mahajan A., Lagou V., Marullo L., Ferreira T., Miraglio B., Timonen S., Kettunen J., Pirinen M., Karjalainen J., Thorleifsson G., Hägg S., Hottenga JJ, Isaacs A., Ladenvall C., Beekman M., Esko T., et al. Nature genetics, 2015/05/11, (2015) Read More / View Supplemental Materials
Abstract
Cell Specific eQTL Analysis without Sorting Cells.Westra, HJ, Arends D., Esko T., Peters MJ, Schurmann C., Schramm K., Kettunen J., Yaghootkar H., Fairfax BP, Andiappan AK, Li Y., Fu J., Karjalainen J., Platteel M., Visschedijk M., Weersma RK, Kasela S., Milani L., Tserel L., Peterson P., et al. PLoS genetics, 2015/05/01, Volume 11, Issue 5, p.e1005223, (2015) Read More / View Supplemental Materials
Abstract
Genome-wide Analysis of Body Proportion Classifies Height-Associated Variants by Mechanism of Action and Implicates Genes Important for Skeletal Development.Chan, Y., Salem RM, Hsu YH, McMahon G., Pers TH, Vedantam S., Esko T., Guo MH, Lim ET, GIANT Consortium, Franke L., Smith GD, Strachan DP, and Hirschhorn JN American journal of human genetics, 2015/04/08, (2015) Read More / View Supplemental Materials
Abstract
A Meta-analysis of Gene Expression Signatures of Blood Pressure and Hypertension.Huan, T., Esko T., Peters MJ, Pilling LC, Schramm K., Schurmann C., Chen BH, Liu C., Joehanes R., Johnson AD, Yao C., Ying SX, Courchesne P., Milani L., Raghavachari N., Wang R., Liu P., Reinmaa E., Dehghan A., Hofman A., et al. PLoS genetics, 2015/03/01, Volume 11, Issue 3, p.e1005035, (2015) Read More / View Supplemental Materials
Abstract
Age- and Sex-Specific Causal Effects of Adiposity on Cardiovascular Risk Factors.Fall, T., Hägg S., Ploner A., Mägi R., Fischer K., Draisma HH, Sarin AP, Benyamin B., Ladenvall C., Åkerlund M., Kals M., Esko T., Nelson CP, Kaakinen M., Huikari V., Mangino M., Meirhaeghe A., Kristiansson K., Nuotio ML, Kobl M., et al. Diabetes, 2015/02/23, (2015) Read More / View Supplemental Materials
Abstract
Genetic studies of body mass index yield new insights for obesity biology.Locke, AE, Kahali B., Berndt SI, Justice AE, Pers TH, Day FR, Powell C., Vedantam S., Buchkovich ML, Yang J., Croteau-Chonka DC, Esko T., Fall T., Ferreira T., Gustafsson S., Kutalik Z., Luan J., Mägi R., Randall JC, Winkler TW, et al. Nature, 2015/02/12, Volume 518, Issue 7538, p.197-206, (2015) Read More / View Supplemental Materials
Abstract
New genetic loci link adipose and insulin biology to body fat distribution.Shungin, D., Winkler TW, Croteau-Chonka DC, Ferreira T., Locke AE, Mägi R., Strawbridge RJ, Pers TH, Fischer K., Justice AE, Workalemahu T., Wu JM, Buchkovich ML, Heard-Costa NL, Roman TS, Drong AW, Song C., Gustafsson S., Day FR, Esko T., et al. Nature, 2015/02/12, Volume 518, Issue 7538, p.187-96, (2015) Read More / View Supplemental Materials
Abstract
Dominance Genetic Variation Contributes Little to the Missing Heritability for Human Complex Traits.Zhu, Z., Bakshi A., Vinkhuyzen AA, Hemani G., Lee SH, Nolte IM, van Vliet-Ostaptchouk JV, Snieder H., The LifeLines Cohort Study, Esko T., Milani L., Mägi R., Metspalu A., Hill WG, Weir BS, Goddard ME, Visscher PM, and Yang J. American journal of human genetics, 2015/02/11, (2015) Read More / View Supplemental Materials
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Biological interpretation of genome-wide association studies using predicted gene functions.Pers, TH, Karjalainen JM, Chan Y., Westra HJ, Wood AR, Yang J., Lui JC, Vedantam S., Gustafsson S., Esko T., Frayling T., Speliotes EK, Genetic Investigation of ANthropometric Traits(GIANT) Consortium, Boehnke M., Raychaudhuri S., Fehrmann RS, Hirschhorn JN, and Franke L. Nature communications, 2015/01/19, Volume 6, p.5890, (2015) Read More / View Supplemental Materials
Abstract
Haplotype phasing and inheritance of copy number variants in nuclear families.Palta, P., Kaplinski L., Nagirnaja L., Veidenberg A., Möls M., Nelis M., Esko T., Metspalu A., Laan M., and Remm M. PloS one, 2015/01/01, Volume 10, Issue 4, p.e0122713, (2015) Read More / View Supplemental Materials
Abstract
Modulation of genetic associations with serum urate levels by body-mass-index in humans.Huffman, JE, Albrecht E., Teumer A., Mangino M., Kapur K., Johnson T., Kutalik Z., Pirastu N., Pistis G., Lopez LM, Haller T., Salo P., Goel A., Li M., Tanaka T., Dehghan A., Ruggiero D., Malerba G., Smith AV, Nolte IM, et al. PloS one, 2015/01/01, Volume 10, Issue 3, p.e0119752, (2015) Read More / View Supplemental Materials
Abstract
Within-trait heterogeneity in age group differences in personality domains and facets: implications for the development and coherence of personality traits.Mõttus, R., Realo A., Allik J., Esko T., Metspalu A., and Johnson W. PloS one, 2015/01/01, Volume 10, Issue 3, p.e0119667, (2015) Read More / View Supplemental Materials
Abstract
2014
Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis.Benyamin, B., Esko T., Ried JS, Radhakrishnan A., Vermeulen SH, Traglia M., Gögele M., Anderson D., Broer L., Podmore C., Luan J., Kutalik Z., Sanna S., van der Meer P., Tanaka T., Wang F., Westra HJ, Franke L., Mihailov E., Milani L., et al. Nature communications, 2014/10/29, Volume 5, p.4926, (2014) Read More / View Supplemental Materials
Abstract
Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption.The Coffee and Caffeine Genetics, Consortium, Cornelis MC, Byrne EM, Esko T., Nalls MA, Ganna A., Paynter N., Monda KL, Amin N., Fischer K., Renstrom F., Ngwa JS, Huikari V., Cavadino A., Nolte IM, Teumer A., Yu K., Marques-Vidal P., Rawal R., Manichaikul A., et al. Molecular psychiatry, 2014/10/07, (2014) Read More / View Supplemental Materials
Abstract
Defining the role of common variation in the genomic and biological architecture of adult human height.Wood, AR, Esko T., Yang J., Vedantam S., Pers TH, Gustafsson S., Chu AY, Estrada K., Luan J., Kutalik Z., Amin N., Buchkovich ML, Croteau-Chonka DC, Day FR, Duan Y., Fall T., Fehrmann R., Ferreira T., Jackson AU, Karjalainen J., et al. Nature genetics, 2014/10/05, (2014) Read More / View Supplemental Materials
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Hemani et al. reply.Hemani, G., Shakhbazov K., Westra HJ, Esko T., Henders AK, McRae AF, Yang J., Gibson G., Martin NG, Metspalu A., Franke L., Montgomery GW, Visscher PM, and Powell JE Nature, 2014/10/02, Volume 514, Issue 7520, p.E5-6, (2014) Read More / View Supplemental Materials
Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.Rietveld, CA, Esko T., Davies G., Pers TH, Turley P., Benyamin B., Chabris CF, Emilsson V., Johnson AD, Lee JJ, de Leeuw C., Marioni RE, Medland SE, Miller MB, Rostapshova O., van der Lee SJ, Vinkhuyzen AA, Amin N., Conley D., Derringer J., et al. Proceedings of the National Academy of Sciences of the United States of America, 2014/09/08, (2014) Read More / View Supplemental Materials
Abstract
Meta-analysis identifies loci affecting levels of the potential osteoarthritis biomarkers sCOMP and uCTX-II with genome wide significance.Ramos, YF, Metrustry S., Arden N., Bay-Jensen AC, Beekman M., de Craen AJ, Cupples LA, Esko T., Evangelou E., Felson DT, Hart DJ, Ioannidis JP, Karsdal M., Kloppenburg M., Lafeber F., Metspalu A., Panoutsopoulou K., Slagboom PE, Spector TD, van Spil EW, et al. Journal of medical genetics, 2014/07/23, (2014) Read More / View Supplemental Materials
Abstract
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.Perry, JR, Day F., Elks CE, Sulem P., Thompson DJ, Ferreira T., He C., Chasman DI, Esko T., Thorleifsson G., Albrecht E., Ang WQ, Corre T., Cousminer DL, Feenstra B., Franceschini N., Ganna A., Johnson AD, Kjellqvist S., Lunetta KL, et al. Nature, 2014/07/23, (2014) Read More / View Supplemental Materials
Abstract
Distribution and Medical Impact of Loss-of-Function Variants in the Finnish Founder Population.Lim, ET, Würtz P., Havulinna AS, Palta P., Tukiainen T., Rehnström K., Esko T., Mägi R., Inouye M., Lappalainen T., Chan Y., Salem RM, Lek M., Flannick J., Sim X., Manning A., Ladenvall C., Bumpstead S., Hämäläinen E., Aalto K., et al. PLoS genetics, 2014/07/01, Volume 10, Issue 7, p.e1004494, (2014) Read More / View Supplemental Materials
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Novel Approach Identifies SNPs in SLC2A10 and KCNK9 with Evidence for Parent-of-Origin Effect on Body Mass Index.Hoggart, CJ, Venturini G., Mangino M., Gomez F., Ascari G., Zhao JH, Teumer A., Winkler TW, Tšernikova N., Luan J., Mihailov E., Ehret GB, Zhang W., Lamparter D., Esko T., Macé A., Rüeger S., Bochud PY, Barcella M., Dauvilliers Y., et al. PLoS genetics, 2014/07/01, Volume 10, Issue 7, p.e1004508, (2014) Read More / View Supplemental Materials
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Quality control and conduct of genome-wide association meta-analyses.Winkler, TW, Day FR, Croteau-Chonka DC, Wood AR, Locke AE, Mägi R., Ferreira T., Fall T., Graff M., Justice AE, Luan J., Gustafsson S., Randall JC, Vedantam S., Workalemahu T., Kilpeläinen TO, Scherag A., Esko T., Kutalik Z., Heid IM, et al. Nature protocols, 2014/05/01, Volume 9, Issue 5, p.1192-212, (2014) Read More / View Supplemental Materials
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Detection and replication of epistasis influencing transcription in humans.Hemani, G., Shakhbazov K., Westra HJ, Esko T., Henders AK, McRae AF, Yang J., Gibson G., Martin NG, Metspalu A., Franke L., Montgomery GW, Visscher PM, and Powell JE Nature, 2014/02/26, (2014) Read More / View Supplemental Materials
Abstract
Cohort Profile: Estonian Biobank of the Estonian Genome Center, University of Tartu.Leitsalu, L., Haller T., Esko T., Tammesoo ML, Alavere H., Snieder H., Perola M., Ng PC, Mägi R., Milani L., Fischer K., and Metspalu A. International journal of epidemiology, 2014/02/11, (2014) Read More / View Supplemental Materials
Abstract
Biomarker profiling by nuclear magnetic resonance spectroscopy for the prediction of all-cause mortality: an observational study of 17,345 persons.Fischer, K., Kettunen J., Würtz P., Haller T., Havulinna AS, Kangas AJ, Soininen P., Esko T., Tammesoo ML, Mägi R., Smit S., Palotie A., Ripatti S., Salomaa V., Ala-Korpela M., Perola M., and Metspalu A. PLoS medicine, 2014/02/01, Volume 11, Issue 2, p.e1001606, (2014) Read More / View Supplemental Materials
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2013
Genetics of rheumatoid arthritis contributes to biology and drug discovery.Okada, Y., Wu D., Trynka G., Raj T., Terao C., Ikari K., Kochi Y., Ohmura K., Suzuki A., Yoshida S., Graham RR, Manoharan A., Ortmann W., Bhangale T., Denny JC, Carroll RJ, Eyler AE, Greenberg JD, Kremer JM, Pappas DA, et al. Nature, 2013/12/25, (2013) Read More / View Supplemental Materials
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Common variants associated with plasma triglycerides and risk for coronary artery disease.Do, R., Willer CJ, Schmidt EM, Sengupta S., Gao C., Peloso GM, Gustafsson S., Kanoni S., Ganna A., Chen J., Buchkovich ML, Mora S., Beckmann JS, Bragg-Gresham JL, Chang HY, Demirkan A., Den Hertog HM, Donnelly LA, Ehret GB, Esko T., et al. Nature genetics, 2013/11/01, Volume 45, Issue 11, p.1345-52, (2013) Read More / View Supplemental Materials
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2010
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.Speliotes, EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G., Jackson AU, Allen HL, Lindgren CM, Luan J., Mägi R., Randall JC, Vedantam S., Winkler TW, Qi L., Workalemahu T., Heid IM, Steinthorsdottir V., Stringham HM, Weedon MN, Wheeler E., et al. Nature genetics, 2010/11/01, Volume 42, Issue 11, p.937-48, (2010) Read More / View Supplemental Materials
Abstract
  • Showing 1-36 of 36 Results