Leader of the pack: gene mapping in dogs and other model organisms.

Nat Rev Genet
Authors
Keywords
Abstract

The domestic dog offers a unique opportunity to explore the genetic basis of disease, morphology and behaviour. We share many diseases with our canine companions, including cancer, diabetes and epilepsy, making the dog an ideal model organism for comparative disease genetics. Using newly developed resources, whole-genome association in dog breeds is proving to be exceptionally powerful. Here, we review the different trait-mapping strategies, some key biological findings emerging from recent studies and the implications for human health. We also discuss the development of similar resources for other vertebrate organisms.

Year of Publication
2008
Journal
Nat Rev Genet
Volume
9
Issue
9
Pages
713-25
Date Published
2008 Sep
ISSN
1471-0064
URL
DOI
10.1038/nrg2382
PubMed ID
18714291
Links