Efficient mapping of mendelian traits in dogs through genome-wide association.

Nat Genet

Authors	Elinor Karlsson Izabella Baranowska Claire Wade Nicolette Hillbertz Michael Zody Nathan Anderson Tara Biagi Nick Patterson Gerli Pielberg Edward Kulbokas Kenine Comstock Evan Keller Jill Mesirov Henrik von Euler Olle Kämpe Åke Hedhammar Eric Lander Göran Andersson Leif Andersson Kerstin Lindblad-Toh
Keywords	Animals Female Male Mutation Genome Haplotypes Dogs Chromosome Mapping Polymorphism, Single Nucleotide Promoter Regions, Genetic Genetic Linkage Breeding Melanocytes Hair Color Microphthalmia-Associated Transcription Factor
Abstract	With several hundred genetic diseases and an advantageous genome structure, dogs are ideal for mapping genes that cause disease. Here we report the development of a genotyping array with approximately 27,000 SNPs and show that genome-wide association mapping of mendelian traits in dog breeds can be achieved with only approximately 20 dogs. Specifically, we map two traits with mendelian inheritance: the major white spotting (S) locus and the hair ridge in Rhodesian ridgebacks. For both traits, we map the loci to discrete regions of
Year of Publication	2007
Journal	Nat Genet
Volume	39
Issue	11
Pages	1321-8
Date Published	2007 Nov
ISSN	1546-1718
URL	http://dx.doi.org/10.1038/ng.2007.10
DOI	10.1038/ng.2007.10
PubMed ID	17906626
Links	PubMed DOI Google Scholar