Diastereoselective synthesis of gamma-lactams by a one-pot, four-component reaction.

Org Lett

Authors	Jingqiang Wei Jared Shaw
Keywords	Models, Molecular Lactams Molecular Structure Stereoisomerism Anhydrides Imides
Abstract	A new one-pot, four-component reaction (4CR) between amines, maleic anhydrides, aldehydes, and thiols has been discovered to form tetra- and pentasubstituted gamma-lactams with high diastereoselectivity. Each component is independently variable and employed in equivalent stoichiometry, producing only water as a byproduct.
Year of Publication	2007
Journal	Org Lett
Volume	9
Issue	20
Pages	4077-80
Date Published	2007 Sep 27
ISSN	1523-7060
URL	http://dx.doi.org/10.1021/ol701911u
DOI	10.1021/ol701911u
PubMed ID	17760458
Links	PubMed DOI Google Scholar
Grant list	P50 GM069721 / GM / NIGMS NIH HHS / United States

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