Image-based chemical screening.

Nat Chem Biol
Authors
Keywords
Abstract

Technological advances have made it feasible to conduct high-throughput small-molecule screens based on visual phenotypes of individual cells, using automated imaging and analysis. These screens are rapidly moving from being small, proof-of-principle tests to robust and widespread screens of hundreds of thousands of compounds. Automated imaging screens maximize the information obtained in an initial screen and improve the ability to select high-quality leads. In this Perspective, I highlight the key steps necessary for conducting a high-throughput image-based chemical compound screen.

Year of Publication
2007
Journal
Nat Chem Biol
Volume
3
Issue
8
Pages
461-5
Date Published
2007 Aug
ISSN
1552-4450
URL
DOI
10.1038/nchembio.2007.15
PubMed ID
17637778
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