Place of pattern in proteomic biomarker discovery.
J Proteome Res
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Abstract | The role of pattern in biomarker discovery and clinical diagnosis is examined in its historical context. The use of MS-derived pattern is treated as a logical extension of prior applications of non-MS-derived pattern. Criticisms pertaining to specific technology platforms and analytic methodologies are considered separately from the larger issues of pattern utility and deployment in biomarker discovery. We present a hybrid strategy that marries the desirable attributes of high-information content MS pattern with the capability to obtain identity, and explore the key steps in establishing a data analysis pipeline for pattern-based biomarker discovery. |
Year of Publication | 2005
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Journal | J Proteome Res
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Volume | 4
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Issue | 4
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Pages | 1143-54
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Date Published | 2005 Jul-Aug
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ISSN | 1535-3893
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URL | |
DOI | 10.1021/pr0500962
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PubMed ID | 16083265
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