Paths to understanding the genetic basis of autoimmune disease.

Nature
Authors
Keywords
Abstract

Some people inherit an unfortunate combination of genetic sequences, such that exposure to an external trigger causes their immune response to turn on their own tissues. Although mutations in a single gene can cause autoimmunity, most autoimmune diseases are associated with several sequence variants. Marked advances in genetic resources and tools are now making it possible to identify the sequence variants that contribute to autoimmune diseases--promising a better understanding of how we normally remain tolerant of our own tissue components, and how this goes wrong in autoimmune disease.

Year of Publication
2005
Journal
Nature
Volume
435
Issue
7042
Pages
584-9
Date Published
2005 Jun 02
ISSN
1476-4687
URL
DOI
10.1038/nature03723
PubMed ID
15931210
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