Transcription factor-mediated epigenetic reprogramming.

J Biol Chem
Authors
Keywords
Abstract

Input from various signaling pathways in conjunction with specific transcription factors (TFs), noncoding RNAs, and epigenetic modifiers governs the maintenance of cellular identity. Endogenous or exogenous TFs operate within certain boundaries, which are set, in part, by the cell type-specific epigenetic landscape. Ectopic expression of selected TFs can override the cellular identity and induce reprogramming to alternative fates. In this minireview, we summarize many of the classic examples and a large number of recent studies that have taken advantage of TF-mediated reprogramming to produce cell types of biomedical relevance.

Year of Publication
2012
Journal
J Biol Chem
Volume
287
Issue
37
Pages
30922-31
Date Published
2012 Sep 07
ISSN
1083-351X
URL
DOI
10.1074/jbc.R111.319046
PubMed ID
22952239
PubMed Central ID
PMC3438925
Links
Grant list
P01 GM099117 / GM / NIGMS NIH HHS / United States
U01 ES017155 / ES / NIEHS NIH HHS / United States
P01GM099117 / GM / NIGMS NIH HHS / United States
U01ES017155 / ES / NIEHS NIH HHS / United States