Lessons from the cancer genome.

Cell
Authors
Keywords
Abstract

Systematic studies of the cancer genome have exploded in recent years. These studies have revealed scores of new cancer genes, including many in processes not previously known to be causal targets in cancer. The genes affect cell signaling, chromatin, and epigenomic regulation; RNA splicing; protein homeostasis; metabolism; and lineage maturation. Still, cancer genomics is in its infancy. Much work remains to complete the mutational catalog in primary tumors and across the natural history of cancer, to connect recurrent genomic alterations to altered pathways and acquired cellular vulnerabilities, and to use this information to guide the development and application of therapies.

Year of Publication
2013
Journal
Cell
Volume
153
Issue
1
Pages
17-37
Date Published
2013 Mar 28
ISSN
1097-4172
URL
DOI
10.1016/j.cell.2013.03.002
PubMed ID
23540688
Links