From genetics of inflammatory bowel disease towards mechanistic insights.

Trends Immunol
Authors
Keywords
Abstract

Advancements in human genetics now poise the field to illuminate the pathophysiology of complex genetic disease. In particular, genome-wide association studies (GWAS) have generated insights into the mechanisms driving inflammatory bowel disease (IBD) and implicated genes shared by multiple autoimmune and autoinflammatory diseases. Thus, emerging evidence suggests a central role for the mucosal immune system in mediating immune homeostasis and highlights the complexity of genetic and environmental interactions that collectively modulate the risk of disease. Nevertheless, the challenge remains to determine how genetic variation can precipitate and sustain the inappropriate inflammatory response to commensals that is observed in IBD. Here, we highlight recent advancements in immunogenetics and provide a forward-looking view of the innovations that will deliver mechanistic insights from human genetics.

Year of Publication
2013
Journal
Trends Immunol
Volume
34
Issue
8
Pages
371-8
Date Published
2013 Aug
ISSN
1471-4981
URL
DOI
10.1016/j.it.2013.04.001
PubMed ID
23639549
PubMed Central ID
PMC3735683
Links
Grant list
R01 DK092405 / DK / NIDDK NIH HHS / United States