Progress in the genetics of polygenic brain disorders: significant new challenges for neurobiology.

Neuron
Authors
Keywords
Abstract

Advances in genome analysis, accompanied by the assembly of large patient cohorts, are making possible successful genetic analyses of polygenic brain disorders. If the resulting molecular clues, previously hidden in the genomes of affected individuals, are to yield useful information about pathogenesis and inform the discovery of new treatments, neurobiology will have to rise to many difficult challenges. Here we review the underlying logic of the genetic investigations, describe in more detail progress in schizophrenia and autism, and outline the challenges for neurobiology that lie ahead. We argue that technologies at the disposal of neuroscience are adequately advanced to begin to study the biology of common and devastating polygenic disorders.

Year of Publication
2013
Journal
Neuron
Volume
80
Issue
3
Pages
578-87
Date Published
2013 Oct 30
ISSN
1097-4199
URL
DOI
10.1016/j.neuron.2013.10.046
PubMed ID
24183011
PubMed Central ID
PMC4066986
Links
Grant list
R01 HG006855 / HG / NHGRI NIH HHS / United States