Synthesis of piperlogs and analysis of their effects on cells.

Tetrahedron
Authors
Abstract

Piperlongumine (PL) is a naturally occurring small molecule previously shown to induce cell death preferentially in cancer cells relative to non-cancer cells. An initial effort to synthesize analogs highlighted the reactivities of both of piperlongumine's α,β-unsaturated imide functionalities as key features determining PL's cellular effects. In this study, a second-generation of analogs was synthesized and evaluated in cells to gain further insight into how the reactivity, number, and orientation of PL's reactive olefins contribute to its ability to alter the physiology of cells.

Year of Publication
2013
Journal
Tetrahedron
Volume
69
Issue
36
Date Published
2013 Sep 09
ISSN
0040-4020
DOI
10.1016/j.tet.2013.05.080
PubMed ID
24273350
PubMed Central ID
PMC3834962
Links
Grant list
R01 GM038627 / GM / NIGMS NIH HHS / United States