The multilayered complexity of ceRNA crosstalk and competition.

Nature
Authors
Keywords
Abstract

Recent reports have described an intricate interplay among diverse RNA species, including protein-coding messenger RNAs and non-coding RNAs such as long non-coding RNAs, pseudogenes and circular RNAs. These RNA transcripts act as competing endogenous RNAs (ceRNAs) or natural microRNA sponges - they communicate with and co-regulate each other by competing for binding to shared microRNAs, a family of small non-coding RNAs that are important post-transcriptional regulators of gene expression. Understanding this novel RNA crosstalk will lead to significant insight into gene regulatory networks and have implications in human development and disease.

Year of Publication
2014
Journal
Nature
Volume
505
Issue
7483
Pages
344-52
Date Published
2014 Jan 16
ISSN
1476-4687
URL
DOI
10.1038/nature12986
PubMed ID
24429633
PubMed Central ID
PMC4113481
Links
Grant list
R01 CA082328 / CA / NCI NIH HHS / United States
R01 CA170158 / CA / NCI NIH HHS / United States
R01 CA-82328 / CA / NCI NIH HHS / United States