Meta-analysis of genome-wide association studies identifies 1q22 as a susceptibility locus for intracerebral hemorrhage.

Am J Hum Genet
Authors
Daniel Woo
Guido Falcone
William Devan
W Mark Brown
Alessandro Biffi
Timothy Howard
Christopher Anderson
H Bart Brouwers
Valerie Valant
Thomas Battey
Farid Radmanesh
Miriam Raffeld
Sylvia Baedorf-Kassis
Ranjan Deka
Jessica Woo
Lisa Martin
Mary Haverbusch
Charles Moomaw
Guangyun Sun
Joseph Broderick
Matthew Flaherty
Sharyl Martini
Dawn Kleindorfer
Brett Kissela
Mary Comeau
Jeremiasz Jagiella
Helena Schmidt
Paul Freudenberger
Alexander Pichler
Christian Enzinger
Björn Hansen
Bo Norrving
Jordi Jimenez-Conde
Eva Giralt-Steinhauer
Roberto Elosua
Elisa Cuadrado-Godia
Carolina Soriano
Jaume Roquer
Peter Kraft
Alison Ayres
Kristin Schwab
Jacob McCauley
Joanna Pera
Andrzej Urbanik
Natalia Rost
Joshua Goldstein
Anand Viswanathan
Eva-Maria Stögerer
David Tirschwell
Magdy Selim
Devin Brown
Scott Silliman
Bradford Worrall
James Meschia
Chelsea Kidwell
Joan Montaner
Israel Fernandez-Cadenas
Pilar Delgado
Rainer Malik
Martin Dichgans
Steven Greenberg
Peter Rothwell
Arne Lindgren
Agnieszka Slowik
Reinhold Schmidt
Carl Langefeld
Jonathan Rosand
International Stroke Genetics Consortium
Keywords
Humans
Genetic Predisposition to Disease
Genome-Wide Association Study
Quantitative Trait Loci
Case-Control Studies
Chromosomes, Human, Pair 1
Cerebral Hemorrhage
Abstract

Intracerebral hemorrhage (ICH) is the stroke subtype with the worst prognosis and has no established acute treatment. ICH is classified as lobar or nonlobar based on the location of ruptured blood vessels within the brain. These different locations also signal different underlying vascular pathologies. Heritability estimates indicate a substantial genetic contribution to risk of ICH in both locations. We report a genome-wide association study of this condition that meta-analyzed data from six studies that enrolled individuals of European ancestry. Case subjects were ascertained by neurologists blinded to genotype data and classified as lobar or nonlobar based on brain computed tomography. ICH-free control subjects were sampled from ambulatory clinics or random digit dialing. Replication of signals identified in the discovery cohort with p

Year of Publication
2014
Journal
Am J Hum Genet
Volume
94
Issue
4
Pages
511-21
Date Published
2014 Apr 03
ISSN
1537-6605
URL
http://linkinghub.elsevier.com/retrieve/pii/S0002-9297(14)00070-6
DOI
10.1016/j.ajhg.2014.02.012
PubMed ID
24656865
PubMed Central ID
PMC3980413
Links
Grant list
K23 NS059774 / NS / NINDS NIH HHS / United States
5K23NS059774 / NS / NINDS NIH HHS / United States
095626 / Wellcome Trust / United Kingdom
R01 NS070941 / NS / NINDS NIH HHS / United States
R01 NS030678 / NS / NINDS NIH HHS / United States
R01 NS062675 / NS / NINDS NIH HHS / United States
T32 NS047996 / NS / NINDS NIH HHS / United States
P50NS061343 / NS / NINDS NIH HHS / United States
R01 HL098065 / HL / NHLBI NIH HHS / United States
NS069763 / NS / NINDS NIH HHS / United States
U10 NS077311 / NS / NINDS NIH HHS / United States
R18 HS017690 / HS / AHRQ HHS / United States
U01 NS069763 / NS / NINDS NIH HHS / United States
R01 NS059727 / NS / NINDS NIH HHS / United States
NS30678 / NS / NINDS NIH HHS / United States
NS36695 / NS / NINDS NIH HHS / United States
U01 NS074425 / NS / NINDS NIH HHS / United States
UL1 TR001425 / TR / NCATS NIH HHS / United States
R01NS059727 / NS / NINDS NIH HHS / United States
R01 NS036695 / NS / NINDS NIH HHS / United States
M01 RR000042 / RR / NCRR NIH HHS / United States
Wellcome Trust / United Kingdom

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