Improving and accelerating drug development for nervous system disorders.

Neuron
Authors
Keywords
Abstract

Advances in the neurosciences have placed the field in the position where it is poised to significantly reduce the burden of nervous system disorders. However, drug discovery, development, and translation for nervous system disorders still pose many unique challenges. The key scientific challenges can be summarized as follows: mechanisms of disease, target identification and validation, predictive models, biomarkers for patient stratification and as endpoints for clinical trials, clear regulatory pathways, reliability and reproducibility of published data, and data sharing and collaboration. To accelerate nervous system drug development, the Institute of Medicine's Forum on Neuroscience and Nervous System Disorders has hosted a series of public workshops that brought together representatives of industry, government (including both research funding and regulatory agencies), academia, and patient groups to discuss these challenges and offer potential strategies to improve the translational neuroscience.

Year of Publication
2014
Journal
Neuron
Volume
84
Issue
3
Pages
546-53
Date Published
2014 Nov 05
ISSN
1097-4199
URL
DOI
10.1016/j.neuron.2014.10.007
PubMed ID
25442933
PubMed Central ID
PMC4254615
Links
Grant list
HHSN263201200074I / OD / NIH HHS / United States