Genome-wide association studies of late-onset cardiovascular disease.
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Abstract | Human genetics is a powerful tool for discovering causal mediators of human disease and physiology. Cardiovascular diseases with late onset in the lifecourse have historically not been considered genetic diseases, but in recent years the contribution of a heritable factor has been established. More importantly, over the last decade genome-wide association studies (GWASs) have identified many loci associated with late-onset cardiovascular diseases including coronary artery disease, carotid artery disease, ischemic stroke, aortic aneurysm, peripheral vascular disease, atrial fibrillation, valvular disease and correlates of vascular and myocardial function. Here we review findings from GWASs considered statistically robust with regard to multiple testing (p |
Year of Publication | 2015
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Journal | J Mol Cell Cardiol
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Volume | 83
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Pages | 131-41
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Date Published | 2015 Jun
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ISSN | 1095-8584
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URL | |
DOI | 10.1016/j.yjmcc.2015.04.004
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PubMed ID | 25870159
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PubMed Central ID | PMC4459905
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Grant list | R01 HL113933 / HL / NHLBI NIH HHS / United States
R01 HL124262 / HL / NHLBI NIH HHS / United States
R01HL113933 / HL / NHLBI NIH HHS / United States
R01HL124262 / HL / NHLBI NIH HHS / United States
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