Genome-wide association studies of late-onset cardiovascular disease.

J Mol Cell Cardiol
Authors
Keywords
Abstract

Human genetics is a powerful tool for discovering causal mediators of human disease and physiology. Cardiovascular diseases with late onset in the lifecourse have historically not been considered genetic diseases, but in recent years the contribution of a heritable factor has been established. More importantly, over the last decade genome-wide association studies (GWASs) have identified many loci associated with late-onset cardiovascular diseases including coronary artery disease, carotid artery disease, ischemic stroke, aortic aneurysm, peripheral vascular disease, atrial fibrillation, valvular disease and correlates of vascular and myocardial function. Here we review findings from GWASs considered statistically robust with regard to multiple testing (p

Year of Publication
2015
Journal
J Mol Cell Cardiol
Volume
83
Pages
131-41
Date Published
2015 Jun
ISSN
1095-8584
URL
DOI
10.1016/j.yjmcc.2015.04.004
PubMed ID
25870159
PubMed Central ID
PMC4459905
Links
Grant list
R01 HL113933 / HL / NHLBI NIH HHS / United States
R01 HL124262 / HL / NHLBI NIH HHS / United States
R01HL113933 / HL / NHLBI NIH HHS / United States
R01HL124262 / HL / NHLBI NIH HHS / United States