Role of Autophagy in the Maintenance of Intestinal Homeostasis.

Gastroenterology
Authors
Keywords
Abstract

Genome-wide association studies of inflammatory bowel disease have identified several risk loci in genes that regulate autophagy, and studies have provided insight into the functional effects of these polymorphisms. We review the mechanisms by which autophagy contributes to intestinal homeostasis, focusing on its cell type-specific roles in regulating gut ecology, restricting pathogenic bacteria, and controlling inflammation. Based on this information, we are beginning to understand how alterations in autophagy can contribute to intestinal inflammation.

Year of Publication
2015
Journal
Gastroenterology
Volume
149
Issue
3
Pages
553-62
Date Published
2015 Sep
ISSN
1528-0012
URL
DOI
10.1053/j.gastro.2015.06.046
PubMed ID
26170139
PubMed Central ID
PMC4550567
Links
Grant list
U19 AI109725 / AI / NIAID NIH HHS / United States
DK043351 / DK / NIDDK NIH HHS / United States
U54 DK102557 / DK / NIDDK NIH HHS / United States
P30 DK043351 / DK / NIDDK NIH HHS / United States
DK092405 / DK / NIDDK NIH HHS / United States
R01 DK092405 / DK / NIDDK NIH HHS / United States
DK102557 / DK / NIDDK NIH HHS / United States
DK097485 / DK / NIDDK NIH HHS / United States
R01 DK097485 / DK / NIDDK NIH HHS / United States