Korean Atrial Fibrillation (AF) Network: Genetic Variants for AF Do Not Predict Ablation Success.

J Am Heart Assoc
Authors
Keywords
Abstract

BACKGROUND: Genomewide association studies have identified several loci associated with atrial fibrillation (AF) and have been reportedly associated with response to catheter ablation for AF in patients of European ancestry; however, associations between top susceptibility loci and AF recurrence after ablation have not been examined in Asian populations. We examined whether the top single nucleotide polymorphisms (SNPs) at chromosomes 4q25 (PITX2), 16q22 (ZFHX3), and 1q21 (KCNN3) were associated with AF in a Korean population and whether these SNPs were associated with clinical outcomes after catheter ablation for AF.

METHODS AND RESULTS: We determined the association between 4 SNPs and AF in 1068 AF patients who underwent catheter ablation (74.6% male, aged 57.5±10.9 years, 67.9% paroxysmal AF) and 1068 age- and sex-matched controls. The SNPs at the PITX2 and ZFHX3 loci, but not the KCNN3 locus, were significantly associated with AF (PITX2/rs6843082_G: odds ratio 3.41, 95% CI 2.55 to 4.55, P=1.32×10(-16); PITX2/rs2200733_T: odds ratio 2.05, 95% CI 1.66 to 2.53, P=2.20×10(-11); ZFHX3/rs2106261_A: odds ratio 2.33, 95% CI 1.87 to 2.91, P=3.75×10(-14); KCNN3/rs13376333_T: odds ratio 1.74, 95% CI 0.93 to 3.25, P=0.085). Among those patients who underwent catheter ablation for AF, none of the top AF-associated SNPs were associated with long-term clinical recurrence of AF after catheter ablation.

CONCLUSIONS: SNPs at the PITX2 and ZFHX3 loci were strongly associated with AF in Korean patients. In contrast to prior reports, none of the 4 top AF-susceptibility SNPs predicted clinical recurrence after catheter ablation.

Year of Publication
2015
Journal
J Am Heart Assoc
Volume
4
Issue
8
Pages
e002046
Date Published
2015 Aug 13
ISSN
2047-9980
URL
DOI
10.1161/JAHA.115.002046
PubMed ID
26272656
PubMed Central ID
PMC4599462
Links
Grant list
K23HL114724 / HL / NHLBI NIH HHS / United States
R01HL104156 / HL / NHLBI NIH HHS / United States
R01HL092577 / HL / NHLBI NIH HHS / United States
K24HL105780 / HL / NHLBI NIH HHS / United States
HL065962 / HL / NHLBI NIH HHS / United States
K23 HL114724 / HL / NHLBI NIH HHS / United States