A New Imaging Platform for Visualizing Biological Effects of Non-Invasive Radiofrequency Electric-Field Cancer Hyperthermia.

PLoS One
Authors
Keywords
Abstract

Herein, we present a novel imaging platform to study the biological effects of non-invasive radiofrequency (RF) electric field cancer hyperthermia. This system allows for real-time in vivo intravital microscopy (IVM) imaging of radiofrequency-induced biological alterations such as changes in vessel structure and drug perfusion. Our results indicate that the IVM system is able to handle exposure to high-power electric-fields without inducing significant hardware damage or imaging artifacts. Furthermore, short durations of low-power (

Year of Publication
2015
Journal
PLoS One
Volume
10
Issue
8
Pages
e0136382
Date Published
2015
ISSN
1932-6203
URL
DOI
10.1371/journal.pone.0136382
PubMed ID
26308617
PubMed Central ID
PMC4550384
Links
Grant list
P30 CA016672 / CA / NCI NIH HHS / United States
T32 CA174647 / CA / NCI NIH HHS / United States
CA016672 / CA / NCI NIH HHS / United States
U54 CA143837 / CA / NCI NIH HHS / United States
U54CA143837 / CA / NCI NIH HHS / United States
TL1TR000369 / TR / NCATS NIH HHS / United States
UL1TR000371 / TR / NCATS NIH HHS / United States
TL1 TR000369 / TR / NCATS NIH HHS / United States
UL1 TR000371 / TR / NCATS NIH HHS / United States