Enlisting hESCs to Interrogate Genetic Variants Associated with Neuropsychiatric Disorders.

Cell Stem Cell
Authors
Keywords
Abstract

Connecting rare genetic variants to neuropsychiatric disease mechanisms remains a significant challenge. In this issue of Cell Stem Cell, Pak et al. (2015) combine gene targeting and stem cell technologies to identify a significant cellular effect of rare penetrant NRXN1 mutations in human neurons, which was found to cause a defect in neurotransmitter release.

Year of Publication
2015
Journal
Cell Stem Cell
Volume
17
Issue
3
Pages
253-4
Date Published
2015 Sep 03
ISSN
1875-9777
URL
DOI
10.1016/j.stem.2015.08.013
PubMed ID
26340523
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