Enlisting hESCs to Interrogate Genetic Variants Associated with Neuropsychiatric Disorders.
Cell Stem Cell
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Abstract | Connecting rare genetic variants to neuropsychiatric disease mechanisms remains a significant challenge. In this issue of Cell Stem Cell, Pak et al. (2015) combine gene targeting and stem cell technologies to identify a significant cellular effect of rare penetrant NRXN1 mutations in human neurons, which was found to cause a defect in neurotransmitter release. |
Year of Publication | 2015
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Journal | Cell Stem Cell
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Volume | 17
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Issue | 3
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Pages | 253-4
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Date Published | 2015 Sep 03
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ISSN | 1875-9777
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URL | |
DOI | 10.1016/j.stem.2015.08.013
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PubMed ID | 26340523
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