Modeling psychiatric disorders for developing effective treatments.

Nat Med
Authors
Keywords
Abstract

Recent advances in identifying risk-associated genes have provided unprecedented opportunities for developing animal models for psychiatric disease research with the goal of attaining translational utility to ultimately develop novel treatments. However, at this early stage, successful translation has yet to be achieved. Here we review recent advances in modeling psychiatric disease, discuss the utility and limitations of animal models, and emphasize the importance of shifting from behavioral analysis to identifying neurophysiological abnormalities, which are likely to be more conserved across species and thus may increase translatability. Looking forward, we envision that preclinical research will align with clinical research to build a common framework of comparable neurobiological abnormalities and to help form subgroups of patients on the basis of similar pathophysiology. Experimental neuroscience can then use animal models to discover mechanisms underlying distinct abnormalities and develop strategies for effective treatments.

Year of Publication
2015
Journal
Nat Med
Volume
21
Issue
9
Pages
979-88
Date Published
2015 Sep
ISSN
1546-170X
URL
DOI
10.1038/nm.3935
PubMed ID
26340119
PubMed Central ID
PMC4886231
Links
Grant list
R01 MH097104 / MH / NIMH NIH HHS / United States
5R01MH097104 / MH / NIMH NIH HHS / United States