Insights into the Genetic Susceptibility to Type 2 Diabetes from Genome-Wide Association Studies of Obesity-Related Traits.

Curr Diab Rep
Authors
Keywords
Abstract

Obesity and type 2 diabetes (T2D) are common and complex metabolic diseases, which are caused by an interchange between environmental and genetic factors. Recently, a number of large-scale genome-wide association studies (GWAS) have improved our knowledge of the genetic architecture and biological mechanisms of these diseases. Currently, more than ~250 genetic loci have been found for monogenic, syndromic, or common forms of T2D and/or obesity-related traits. In this review, we discuss the implications of these GWAS for obesity and T2D, and investigate the overlap of loci for obesity-related traits and T2D, highlighting potential mechanisms that affect T2D susceptibility.

Year of Publication
2015
Journal
Curr Diab Rep
Volume
15
Issue
10
Pages
83
Date Published
2015 Oct
ISSN
1539-0829
URL
DOI
10.1007/s11892-015-0648-8
PubMed ID
26363598
PubMed Central ID
PMC4568008
Links
Grant list
086596/Z/08/Z / Wellcome Trust / United Kingdom