Applications of CRISPR-Cas systems in neuroscience.

Nat Rev Neurosci
Authors
Keywords
Abstract

Genome-editing tools, and in particular those based on CRISPR-Cas (clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-associated protein) systems, are accelerating the pace of biological research and enabling targeted genetic interrogation in almost any organism and cell type. These tools have opened the door to the development of new model systems for studying the complexity of the nervous system, including animal models and stem cell-derived in vitro models. Precise and efficient gene editing using CRISPR-Cas systems has the potential to advance both basic and translational neuroscience research.

Year of Publication
2016
Journal
Nat Rev Neurosci
Volume
17
Issue
1
Pages
36-44
Date Published
2016 Jan
ISSN
1471-0048
URL
DOI
10.1038/nrn.2015.2
PubMed ID
26656253
PubMed Central ID
PMC4899966
Links
Grant list
R01 MH110049 / MH / NIMH NIH HHS / United States
5DP1-MH100706 / DP / NCCDPHP CDC HHS / United States
1R01-MH110049 / MH / NIMH NIH HHS / United States
DP1 MH100706 / MH / NIMH NIH HHS / United States
5R01DK097768-03 / DK / NIDDK NIH HHS / United States