Comprehensive analysis of schizophrenia-associated loci highlights ion channel pathways and biologically plausible candidate causal genes.
Hum Mol Genet
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Abstract | Over 100 associated genetic loci have been robustly associated with schizophrenia. Gene prioritization and pathway analysis have focused on a priori hypotheses and thus may have been unduly influenced by prior assumptions and missed important causal genes and pathways. Using a data-driven approach, we show that genes in associated loci: (1) are highly expressed in cortical brain areas; (2) are enriched for ion channel pathways (false discovery rates |
Year of Publication | 2016
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Journal | Hum Mol Genet
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Volume | 25
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Issue | 6
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Pages | 1247-54
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Date Published | 2016 Mar 15
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ISSN | 1460-2083
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URL | |
DOI | 10.1093/hmg/ddw007
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PubMed ID | 26755824
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PubMed Central ID | PMC4764200
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Grant list | T32 GM074905 / GM / NIGMS NIH HHS / United States
T32GM074905 / GM / NIGMS NIH HHS / United States
R01 DK075787 / DK / NIDDK NIH HHS / United States
U01MH094421 / MH / NIMH NIH HHS / United States
2R01DK075787 / DK / NIDDK NIH HHS / United States
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