Comprehensive analysis of schizophrenia-associated loci highlights ion channel pathways and biologically plausible candidate causal genes.

Hum Mol Genet
Authors
Keywords
Abstract

Over 100 associated genetic loci have been robustly associated with schizophrenia. Gene prioritization and pathway analysis have focused on a priori hypotheses and thus may have been unduly influenced by prior assumptions and missed important causal genes and pathways. Using a data-driven approach, we show that genes in associated loci: (1) are highly expressed in cortical brain areas; (2) are enriched for ion channel pathways (false discovery rates

Year of Publication
2016
Journal
Hum Mol Genet
Volume
25
Issue
6
Pages
1247-54
Date Published
2016 Mar 15
ISSN
1460-2083
URL
DOI
10.1093/hmg/ddw007
PubMed ID
26755824
PubMed Central ID
PMC4764200
Links
Grant list
T32 GM074905 / GM / NIGMS NIH HHS / United States
T32GM074905 / GM / NIGMS NIH HHS / United States
R01 DK075787 / DK / NIDDK NIH HHS / United States
U01MH094421 / MH / NIMH NIH HHS / United States
2R01DK075787 / DK / NIDDK NIH HHS / United States