Genetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept.

Nat Neurosci
Authors
Keywords
Abstract

Schizophrenia is a devastating psychiatric illness with high heritability. Brain structure and function differ, on average, between people with schizophrenia and healthy individuals. As common genetic associations are emerging for both schizophrenia and brain imaging phenotypes, we can now use genome-wide data to investigate genetic overlap. Here we integrated results from common variant studies of schizophrenia (33,636 cases, 43,008 controls) and volumes of several (mainly subcortical) brain structures (11,840 subjects). We did not find evidence of genetic overlap between schizophrenia risk and subcortical volume measures either at the level of common variant genetic architecture or for single genetic markers. These results provide a proof of concept (albeit based on a limited set of structural brain measures) and define a roadmap for future studies investigating the genetic covariance between structural or functional brain phenotypes and risk for psychiatric disorders.

Year of Publication
2016
Journal
Nat Neurosci
Volume
19
Issue
3
Pages
420-31
Date Published
2016 Mar
ISSN
1546-1726
URL
DOI
10.1038/nn.4228
PubMed ID
26854805
PubMed Central ID
PMC4852730
Links
Grant list
090532/Z/09/Z / Wellcome Trust / United Kingdom
RC2 MH089951 / MH / NIMH NIH HHS / United States
R01 MH061675 / MH / NIMH NIH HHS / United States
K23 MH001760 / MH / NIMH NIH HHS / United States
P41 EB015922 / EB / NIBIB NIH HHS / United States
MH065580 / MH / NIMH NIH HHS / United States
U01 MH085520 / MH / NIMH NIH HHS / United States
MH79470 / MH / NIMH NIH HHS / United States
K99 MH102357 / MH / NIMH NIH HHS / United States
R01 MH062873 / MH / NIMH NIH HHS / United States
British Heart Foundation / United Kingdom
R01 MH095034 / MH / NIMH NIH HHS / United States
MH59565 / MH / NIMH NIH HHS / United States
R01 MH078075 / MH / NIMH NIH HHS / United States
R01 MH081802 / MH / NIMH NIH HHS / United States
K99 MH101367 / MH / NIMH NIH HHS / United States
R01MH077139 / MH / NIMH NIH HHS / United States
MH60870 / MH / NIMH NIH HHS / United States
G1100616 / Medical Research Council / United Kingdom
MH59586 / MH / NIMH NIH HHS / United States
R01 MH061884 / MH / NIMH NIH HHS / United States
MH061884 / MH / NIMH NIH HHS / United States
R01 MH058693 / MH / NIMH NIH HHS / United States
93558 / Medical Research Council / United Kingdom
U24 AG021886 / AG / NIA NIH HHS / United States
MH60879 / MH / NIMH NIH HHS / United States
RC2 MH089995 / MH / NIMH NIH HHS / United States
R01 MH084098 / MH / NIMH NIH HHS / United States
WT 083948/Z/07/Z / Wellcome Trust / United Kingdom
U01 MH046276 / MH / NIMH NIH HHS / United States
R01 MH077139 / MH / NIMH NIH HHS / United States
1RC2 MH089951 / MH / NIMH NIH HHS / United States
R01 AG040060 / AG / NIA NIH HHS / United States
104036 / Wellcome Trust / United Kingdom
NIMH K01 MH085812 / PHS HHS / United States
MH46289 / MH / NIMH NIH HHS / United States
K01 MH085812 / MH / NIMH NIH HHS / United States
MH083094 / MH / NIMH NIH HHS / United States
R01 EB005846 / EB / NIBIB NIH HHS / United States
R01 MH094343 / MH / NIMH NIH HHS / United States
U01 AG024904 / AG / NIA NIH HHS / United States
K01 MH065580 / MH / NIMH NIH HHS / United States
G0801418 / Medical Research Council / United Kingdom
MH59571 / MH / NIMH NIH HHS / United States
MH085542 / MH / NIMH NIH HHS / United States
076113/C/04/Z / Wellcome Trust / United Kingdom
U01 MH079469 / MH / NIMH NIH HHS / United States
MR/L016400/1 / Medical Research Council / United Kingdom
P50 MH080272 / MH / NIMH NIH HHS / United States
R01 MH071681 / MH / NIMH NIH HHS / United States
R01MH62873 / MH / NIMH NIH HHS / United States
R01 DK075787 / DK / NIDDK NIH HHS / United States
R01 MH068881 / MH / NIMH NIH HHS / United States
MR/K026992/1 / Medical Research Council / United Kingdom
MH071681 / MH / NIMH NIH HHS / United States
R01 MH067257 / MH / NIMH NIH HHS / United States
MH 41953 / MH / NIMH NIH HHS / United States
R01 MH068922 / MH / NIMH NIH HHS / United States
R01 MH060870 / MH / NIMH NIH HHS / United States
MH52618 / MH / NIMH NIH HHS / United States
R01 MH081800 / MH / NIMH NIH HHS / United States
R01 MH062276 / MH / NIMH NIH HHS / United States
MH001760 / MH / NIMH NIH HHS / United States
R01 MH059571 / MH / NIMH NIH HHS / United States
MH58693 / MH / NIMH NIH HHS / United States
R01 MH059565 / MH / NIMH NIH HHS / United States
R01 MH041953 / MH / NIMH NIH HHS / United States
U54 EB020403 / EB / NIBIB NIH HHS / United States
R00 MH102357 / MH / NIMH NIH HHS / United States
R01 HD050735 / HD / NICHD NIH HHS / United States
R01 EB008432 / EB / NIBIB NIH HHS / United States
R01 AG033193 / AG / NIA NIH HHS / United States
MH61675 / MH / NIMH NIH HHS / United States
U01 MH079470 / MH / NIMH NIH HHS / United States
MH46276 / MH / NIMH NIH HHS / United States
MH46318 / MH / NIMH NIH HHS / United States
R01 MH059587 / MH / NIMH NIH HHS / United States
G0800509 / Medical Research Council / United Kingdom
K01 MH099232 / MH / NIMH NIH HHS / United States
MH67257 / MH / NIMH NIH HHS / United States
R01D0042157-01A / PHS HHS / United States
R01 MH085548 / MH / NIMH NIH HHS / United States
R01 MH089722 / MH / NIMH NIH HHS / United States
085475/B/08/Z / Wellcome Trust / United Kingdom
R01 MH059586 / MH / NIMH NIH HHS / United States
076113/CI04/Z / Wellcome Trust / United Kingdom
068545/Z/0 / Wellcome Trust / United Kingdom
NIMH RC2 MH089964 / RC / CCR NIH HHS / United States
U01 MH046289 / MH / NIMH NIH HHS / United States
RC2 MH089964 / MH / NIMH NIH HHS / United States
MH81800 / MH / NIMH NIH HHS / United States
NIMH R01 MH100141 / PHS HHS / United States
R01 MH068921 / MH / NIMH NIH HHS / United States
MH59588 / MH / NIMH NIH HHS / United States
1RC2 MH089995 / MH / NIMH NIH HHS / United States
MH79469 / MH / NIMH NIH HHS / United States
R01 MH059566 / MH / NIMH NIH HHS / United States
R01 NS080655 / NS / NINDS NIH HHS / United States
MH068881 / MH / NIMH NIH HHS / United States
R01 MH097268 / MH / NIMH NIH HHS / United States
R01 MH083094 / MH / NIMH NIH HHS / United States
068545/Z/02 / Wellcome Trust / United Kingdom
U01 MH094421 / MH / NIMH NIH HHS / United States
R01 MH100141 / MH / NIMH NIH HHS / United States
NIMH K99 MH101367 / PHS HHS / United States
R01 MH059588 / MH / NIMH NIH HHS / United States
U01 MH046318 / MH / NIMH NIH HHS / United States
MH59566 / MH / NIMH NIH HHS / United States
MH085548 / MH / NIMH NIH HHS / United States
R01 MH092380 / MH / NIMH NIH HHS / United States
R01AG040060 / AG / NIA NIH HHS / United States
G0000934 / Medical Research Council / United Kingdom
R01 MH085667 / MH / NIMH NIH HHS / United States
U54 RR020278 / RR / NCRR NIH HHS / United States
NIMH R01 MH078075 / PHS HHS / United States
085475/Z/08/Z / Wellcome Trust / United Kingdom
U01 MH081928 / MH / NIMH NIH HHS / United States
RR026075 / RR / NCRR NIH HHS / United States
R01 MH085542 / MH / NIMH NIH HHS / United States
072894/Z/03/Z / Wellcome Trust / United Kingdom
R01 MH060879 / MH / NIMH NIH HHS / United States
MH59587 / MH / NIMH NIH HHS / United States
WT0618S8 / Wellcome Trust / United Kingdom
K99MH102357 / MH / NIMH NIH HHS / United States
MC_UU_12013/2 / Medical Research Council / United Kingdom
MH081802 / MH / NIMH NIH HHS / United States