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2015
Multilocus heterozygosity and coronary heart disease: nested case-control studies in men and women.Mukamal, KJ, Jensen MK, Pers TH, Pai JK, Kraft P., and Rimm EB PloS one, 2015/01/01, Volume 10, Issue 5, p.e0124847, (2015) Read More / View Supplemental Materials
Abstract
No Evidence for Association of Autism with Rare Heterozygous Point Mutations in Contactin-Associated Protein-Like 2 (CNTNAP2), or in Other Contactin-Associated Proteins or Contactins.Murdoch, JD, Gupta AR, Sanders SJ, Walker MF, Keaney J., Fernandez TV, Murtha MT, Anyanwu S., Ober GT, Raubeson MJ, DiLullo NM, Villa N., Waqar Z., Sullivan C., Gonzalez L., Willsey AJ, Choe SY, Neale BM, Daly M. J., and State MW PLoS genetics, 2015/01/01, Volume 11, Issue 1, p.e1004852, (2015) Read More / View Supplemental Materials
Abstract
A Re-Appraisal of the Early Andean Human Remains from Lauricocha in Peru.Fehren-Schmitz, L., Llamas B., Lindauer S., Tomasto-Cagigao E., Kuzminsky S., Rohland N., Santos FR, Kaulicke P., Valverde G., Richards SM, Nordenfelt S., Seidenberg V., Mallick S., Cooper A., Reich D., and Haak W. PloS one, 2015/01/01, Volume 10, Issue 6, p.e0127141, (2015) Read More / View Supplemental Materials
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A reproducible approach to high-throughput biological data acquisition and integration.Börnigen, D., Moon YS, Rahnavard G., Waldron L., McIver L., Shafquat A., Franzosa EA, Miropolsky L., Sweeney C., Morgan XC, Garrett WS, and Huttenhower C. PeerJ, 2015/01/01, Volume 3, p.e791, (2015) Read More / View Supplemental Materials
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RNA Antisense Purification (RAP) for Mapping RNA Interactions with Chromatin.Engreitz, J., Lander E. S., and Guttman M. Methods in molecular biology (Clifton, N.J.), 2015/01/01, Volume 1262, p.183-97, (2015) Read More / View Supplemental Materials
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Second-generation PLINK: rising to the challenge of larger and richer datasets.Chang, CC, Chow CC, Tellier LC, Vattikuti S., Purcell SM, and Lee JJ GigaScience, 2015/01/01, Volume 4, p.7, (2015) Read More / View Supplemental Materials
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The Shepherds' Tale: A Genome-Wide Study across 9 Dog Breeds Implicates Two Loci in the Regulation of Fructosamine Serum Concentration in Belgian Shepherds.Forsberg, SK, Kierczak M., Ljungvall I., Merveille AC, Gouni V., Wiberg M., Lundgren Willesen J., Hanås S., Lequarré AS, Mejer Sørensen L., Tiret L., McEntee K., Seppälä E., Koch J., Battaille G., Lohi H., Fredholm M., Chetboul V., Häggström J., Carlborg Ö., et al. PloS one, 2015/01/01, Volume 10, Issue 5, p.e0123173, (2015) Read More / View Supplemental Materials
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The Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH): Design of a pharmacogenetic Resource for Type 2 Diabetes.Walford, GA, Colomo N., Todd JN, Billings LK, Fernandez M., Chamarthi B., Warner AS, Davis J., Littleton KR, Hernandez AM, Fanelli RR, Lanier A., Barbato C., Ackerman RJ, Khan SQ, Bui R., Garber L., Stolerman ES, Moore AF, Huang C., et al. PloS one, 2015/01/01, Volume 10, Issue 3, p.e0121553, (2015) Read More / View Supplemental Materials
Abstract
Targeted resequencing of the pericentromere of chromosome 2 linked to constitutional delay of growth and puberty.Cousminer, DL, Leinonen JT, Sarin AP, Chheda H., Surakka I., Wehkalampi K., Ellonen P., Ripatti S., Dunkel L., Palotie A., and Widén E. PloS one, 2015/01/01, Volume 10, Issue 6, p.e0128524, (2015) Read More / View Supplemental Materials
Abstract
TRAF1/C5 but Not PTPRC Variants Are Potential Predictors of Rheumatoid Arthritis Response to Anti-Tumor Necrosis Factor Therapy.Canhão, H., Rodrigues AM, Santos MJ, Carmona-Fernandes D., Bettencourt BF, Cui J., Rocha FL, Canas Silva J., Polido-Pereira J., Pereira Silva JA, Costa JA, Araujo D., Silva C., Santos H., Duarte C., Cáliz R., Filipescu I., Pimentel-Santos F., Branco J., Sainz J., et al. BioMed research international, 2015/01/01, Volume 2015, p.490295, (2015) Read More / View Supplemental Materials
Abstract
Transcriptional profiling defines dynamics of parasite tissue sequestration during malaria infection.Pelle, KG, Oh K., Buchholz K., Narasimhan V., Joice R., Milner DA, Brancucci NM, Ma S., Voss TS, Ketman K., Seydel KB, Taylor TE, Barteneva NS, Huttenhower C., and Marti M. Genome medicine, 2015/01/01, Volume 7, Issue 1, p.19, (2015) Read More / View Supplemental Materials
Abstract
TYK2 Protein-Coding Variants Protect against Rheumatoid Arthritis and Autoimmunity, with No Evidence of Major Pleiotropic Effects on Non-Autoimmune Complex Traits.Diogo, D., Bastarache L., Liao KP, Graham RR, Fulton RS, Greenberg JD, Eyre S., Bowes J., Cui J., Lee A., Pappas DA, Kremer JM, Barton A., Coenen MJ, Franke B., Kiemeney LA, Mariette X., Richard-Miceli C., Canhão H., Fonseca JE, et al. PloS one, 2015/01/01, Volume 10, Issue 4, p.e0122271, (2015) Read More / View Supplemental Materials
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Using modelling to disentangle the relative contributions of zoonotic and anthroponotic transmission: the case of lassa Fever.Lo Iacono, G., Cunningham AA, Fichet-Calvet E., Garry RF, Grant DS, Khan SH, Leach M., Moses LM, Schieffelin JS, Shaffer JG, Webb CT, and Wood JL PLoS neglected tropical diseases, 2015/01/01, Volume 9, Issue 1, p.e3398, (2015) Read More / View Supplemental Materials
Abstract
Within-trait heterogeneity in age group differences in personality domains and facets: implications for the development and coherence of personality traits.Mõttus, R., Realo A., Allik J., Esko T., Metspalu A., and Johnson W. PloS one, 2015/01/01, Volume 10, Issue 3, p.e0119667, (2015) Read More / View Supplemental Materials
Abstract
2014
Increased expression of the immune modulatory molecule PD-L1 (CD274) in anaplastic meningioma.Du, Z., Abedalthagafi M., Aizer AA, McHenry AR, Sun HH, Bray MA, Viramontes O., Machaidze R., Brastianos PK, Reardon DA, Dunn IF, Freeman GJ, Ligon KL, Carpenter AE, Alexander BM, Agar NY, Rodig SJ, Bradshaw EM, and Santagata S. Oncotarget, 2014/12/31, (2014) Read More / View Supplemental Materials
Abstract
DeCoN: Genome-wide Analysis of In Vivo Transcriptional Dynamics during Pyramidal Neuron Fate Selection in Neocortex.Molyneaux, BJ, Goff LA, Brettler AC, Chen H., Brown JR, Hrvatin S., Rinn JL, and Arlotta P. Neuron, 2014/12/30, (2014) Read More / View Supplemental Materials
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Genetic Architecture of White Matter Hyperintensities Differs in Hypertensive and Nonhypertensive Ischemic Stroke.Adib-Samii, P., Devan W., Traylor M., Lanfranconi S., Zhang CR, Cloonan L., Falcone GJ, Radmanesh F., Fitzpatrick K., Kanakis A., Rothwell PM, Sudlow C., Boncoraglio GB, Meschia JF, Levi C., Dichgans M., Bevan S., Rosand J., Rost NS, and Markus HS Stroke; a journal of cerebral circulation, 2014/12/30, (2014) Read More / View Supplemental Materials
Abstract
Target-Based Identification of Whole-Cell Active Inhibitors of Biotin Biosynthesis in Mycobacterium tuberculosis.Park, SW, Casalena DE, Wilson DJ, Dai R., Nag PP, Liu F., Boyce JP, Bittker JA, Schreiber SL, Finzel BC, Schnappinger D., and Aldrich CC Chemistry & biology, 2014/12/30, (2014) Read More / View Supplemental Materials
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Inducible RNAi in vivo reveals that the transcription factor BATF is required to initiate but not maintain CD8+ T-cell effector differentiation.Godec, J., Cowley GS, Barnitz RA, Root DE, Sharpe AH, and Haining WN Proceedings of the National Academy of Sciences of the United States of America, 2014/12/29, (2014) Read More / View Supplemental Materials
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Title (78 characters): A TREM1 variant alters the accumulation of Alzheimer-related amyloid pathology.Replogle, JM, Chan G., White CC, Raj T., Winn PA, Evans DA, Sperling RA, Chibnik LB, Bradshaw EM, Schneider JA, Bennett DA, and De Jager PL Annals of neurology, 2014/12/26, (2014) Read More / View Supplemental Materials
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Dissecting neural differentiation regulatory networks through epigenetic footprinting.Ziller, MJ, Edri R., Yaffe Y., Donaghey J., Pop R., Mallard W., Issner R., Gifford CA, Goren A., Xing J., Gu H., Cacchiarelli D., Tsankov AM, Epstein C., Rinn JL, Mikkelsen TS, Kohlbacher O., Gnirke A., Bernstein BE, Elkabetz Y., et al. Nature, 2014/12/24, (2014) Read More / View Supplemental Materials
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Genetic analysis of schizophrenia and bipolar disorder reveals polygenicity but also suggests new directions for molecular interrogation.Neale, BM, and Sklar P. Current opinion in neurobiology, 2014/12/24, Volume 30C, p.131-138, (2014) Read More / View Supplemental Materials
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The HLA-DRβ1 amino acid positions 11-13-26 explain the majority of SLE-MHC associations.Kim, K., Bang SY, Lee HS, Okada Y., Han B., Saw WY, Teo YY, and Bae SC Nature communications, 2014/12/23, Volume 5, p.5902, (2014) Read More / View Supplemental Materials
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Systematic identification of signaling pathways with potential to confer anticancer drug resistance.Martz, CA, Ottina KA, Singleton KR, Jasper JS, Wardell SE, Peraza-Penton A., Anderson GR, Winter PS, Wang T., Alley HM, Kwong LN, Cooper ZA, Tetzlaff M., Chen PL, Rathmell JC, Flaherty KT, Wargo JA, McDonnell DP, Sabatini DM, and Wood KC Science signaling, 2014/12/23, Volume 7, Issue 357, p.ra121, (2014) Read More / View Supplemental Materials
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The Genetic Ancestry of African Americans, Latinos, and European Americans across the United States.Bryc, K., Durand EY, Macpherson JM, Reich D., and Mountain JL American journal of human genetics, 2014/12/18, (2014) Read More / View Supplemental Materials
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Genetic Variants Associated with Quantitative Glucose Homeostasis Traits Translate to Type 2 Diabetes in Mexican Americans: The GUARDIAN (Genetics Underlying Diabetes in Hispanics) Consortium.Palmer, ND, Goodarzi MO, Langefeld CD, Wang N., Guo X., Taylor KD, Fingerlin TE, Norris JM, Buchanan TA, Xiang AH, Haritunians T., Ziegler JT, Williams AH, Stefansovski D., Cui J., Mackay AW, Henkin LF, Bergman RN, Gao X., Gauderman J., et al. Diabetes, 2014/12/18, (2014) Read More / View Supplemental Materials
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X chromosome reactivation dynamics reveal stages of reprogramming to pluripotency.Pasque, V., Tchieu J., Karnik R., Uyeda M., Sadhu Dimashkie A., Case D., Papp B., Bonora G., Patel S., Ho R., Schmidt R., McKee R., Sado T., Tada T., Meissner A., and Plath K. Cell, 2014/12/18, Volume 159, Issue 7, p.1681-97, (2014) Read More / View Supplemental Materials
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Genetic Predisposition to Dyslipidemia and Risk of Preeclampsia.Spracklen, CN, Saftlas AF, Triche EW, Bjonnes A., Keating B., Saxena R., Breheny PJ, Dewan AT, Robinson JG, Hoh J., and Ryckman KK American journal of hypertension, 2014/12/17, (2014) Read More / View Supplemental Materials
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Katanin p80 Regulates Human Cortical Development by Limiting Centriole and Cilia Number.Hu, WF, Pomp O., Ben-Omran T., Kodani A., Henke K., Mochida GH, Yu TW, Woodworth MB, Bonnard C., Raj GS, Tan TT, Hamamy H., Masri A., Shboul M., Al Saffar M., Partlow JN, Al-Dosari M., Alazami A., Alowain M., Alkuraya FS, et al. Neuron, 2014/12/17, Volume 84, Issue 6, p.1240-57, (2014) Read More / View Supplemental Materials
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The study of psychiatric disease genes and drugs in zebrafish.Haesemeyer, M., and Schier AF Current opinion in neurobiology, 2014/12/16, Volume 30C, p.122-130, (2014) Read More / View Supplemental Materials
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Complementary genomic approaches highlight the PI3K/mTOR pathway as a common vulnerability in osteosarcoma.Perry, JA, Kiezun A., Tonzi P., Van Allen EM, Carter SL, Baca SC, Cowley GS, Bhatt AS, Rheinbay E., Pedamallu CS, Helman E., Taylor-Weiner A., McKenna A., Deluca DS, Lawrence MS, Ambrogio L., Sougnez C., Sivachenko A., Walensky LD, Wagle N., et al. Proceedings of the National Academy of Sciences of the United States of America, 2014/12/15, (2014) Read More / View Supplemental Materials
Abstract
Computational Modeling Predicts IL-10 Control of Lesion Sterilization by Balancing Early Host Immunity-Mediated Antimicrobial Responses with Caseation during Mycobacterium tuberculosis Infection.Cilfone, NA, Ford CB, Marino S., Mattila JT, Gideon HP, Flynn JL, Kirschner DE, and Linderman JJ Journal of immunology (Baltimore, Md. : 1950), 2014/12/15, (2014) Read More / View Supplemental Materials
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De novo CNVs in bipolar affective disorder and schizophrenia.Georgieva, L., Rees E., Moran JL, Chambert KD, Milanova V., Craddock N., Purcell S., Sklar P., McCarroll S., Holmans P., O'Donovan MC, Owen MJ, and Kirov G. Human molecular genetics, 2014/12/15, Volume 23, Issue 24, p.6677-83, (2014) Read More / View Supplemental Materials
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Dilazep analogues for the study of equilibrative nucleoside transporters 1 and 2 (ENT1 and ENT2).Playa, H., Lewis TA, Ting A., Suh BC, Muñoz B., Matuza R., Passer BJ, Schreiber SL, and Buolamwini JK Bioorganic & medicinal chemistry letters, 2014/12/15, Volume 24, Issue 24, p.5801-4, (2014) Read More / View Supplemental Materials
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Genetic modifiers of EGFR dependence in non-small cell lung cancer.Sharifnia, T., Rusu V., Piccioni F., Bagul M., Imielinski M., Cherniack AD, Pedamallu CS, Wong B., Wilson FH, Garraway LA, Altshuler D., Golub T. R., Root DE, Subramanian A., and Meyerson M. Proceedings of the National Academy of Sciences of the United States of America, 2014/12/15, (2014) Read More / View Supplemental Materials
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Identification of nuclear hormone receptor pathways causing insulin resistance by transcriptional and epigenomic analysis.Kang, S., Tsai LT, Zhou Y., Evertts A., Xu S., Griffin MJ, Issner R., Whitton HJ, Garcia BA, Epstein CB, Mikkelsen TS, and Rosen ED Nature cell biology, 2014/12/15, (2014) Read More / View Supplemental Materials
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Pan-cancer network analysis identifies combinations of rare somatic mutations across pathways and protein complexes.Leiserson, MD, Vandin F., Wu H., Dobson JR, Eldridge JV, Thomas JL, Papoutsaki A., Kim Y., Niu B., McLellan M., Lawrence MS, Gonzalez-Perez A., Tamborero D., Cheng Y., Ryslik GA, Lopez-Bigas N., Getz G., Ding L., and Raphael BJ Nature genetics, 2014/12/15, (2014) Read More / View Supplemental Materials
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Core and region-enriched networks of behaviorally regulated genes and the singing genome.Whitney, O., Pfenning AR, Howard JT, Blatti CA, Liu F., Ward JM, Wang R., Audet JN, Kellis M., Mukherjee S., Sinha S., Hartemink AJ, West AE, and Jarvis ED Science (New York, N.Y.), 2014/12/12, Volume 346, Issue 6215, p.1256780, (2014) Read More / View Supplemental Materials
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Familial aggregation of arthritis-related diseases in seropositive and seronegative rheumatoid arthritis: a register-based case-control study in Sweden.Frisell, T., Hellgren K., Alfredsson L., Raychaudhuri S., Klareskog L., and Askling J. Annals of the rheumatic diseases, 2014/12/12, (2014) Read More / View Supplemental Materials
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A 3D Map of the Human Genome at Kilobase Resolution Reveals Principles of Chromatin Looping.Rao, SS, Huntley MH, Durand NC, Stamenova EK, Bochkov ID, Robinson JT, Sanborn AL, Machol I., Omer AD, Lander E. S., and Aiden EL Cell, 2014/12/11, (2014) Read More / View Supplemental Materials
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Integrating phenotypic small-molecule profiling and human genetics: the next phase in drug discovery.Johannessen, CM, Clemons PA, and Wagner BK Trends in genetics : TIG, 2014/12/11, (2014) Read More / View Supplemental Materials
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Single Diastereomer of a Macrolactam Core Binds Specifically to Myeloid Cell Leukemia 1 (MCL1).Fang, C., D'Souza B., Thompson CF, Clifton MC, Fairman JW, Fulroth B., Leed A., McCarren P., Wang L., Wang Y., Feau C., Kaushik VK, Palmer M., Wei G., Golub T. R., Hubbard BK, and Serrano-Wu MH ACS medicinal chemistry letters, 2014/12/11, Volume 5, Issue 12, p.1308-12, (2014) Read More / View Supplemental Materials
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Genome-scale transcriptional activation by an engineered CRISPR-Cas9 complex.Konermann, S., Brigham MD, Trevino AE, Joung J., Abudayyeh OO, Barcena C., Hsu PD, Habib N., Gootenberg JS, Nishimasu H., Nureki O., and Zhang F. Nature, 2014/12/10, (2014) Read More / View Supplemental Materials
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Genome-wide association study of kidney function decline in individuals of European descent.Gorski, M., Tin A., Garnaas M., McMahon GM, Chu AY, Tayo BO, Pattaro C., Teumer A., Chasman DI, Chalmers J., Hamet P., Tremblay J., Woodward M., Aspelund T., Eiriksdottir G., Gudnason V., Harris TB, Launer LJ, Smith AV, Mitchell BD, et al. Kidney international, 2014/12/10, (2014) Read More / View Supplemental Materials
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High-Resolution Sequencing and Modeling Identifies Distinct Dynamic RNA Regulatory Strategies.Rabani, M., Raychowdhury R., Jovanovic M., Rooney M., Stumpo DJ, Pauli A., Hacohen N., Schier AF, Blackshear PJ, Friedman N., Amit I., and Regev A. Cell, 2014/12/10, (2014) Read More / View Supplemental Materials
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Visnagin protects against doxorubicin-induced cardiomyopathy through modulation of mitochondrial malate dehydrogenase.Liu, Y., Asnani A., Zou L., Bentley VL, Yu M., Wang Y., Dellaire G., Sarkar KS, Dai M., Chen HH, Sosnovik DE, Shin JT, Haber DA, Berman JN, Chao W., and Peterson RT Science translational medicine, 2014/12/10, Volume 6, Issue 266, p.266ra170, (2014) Read More / View Supplemental Materials
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Recommendations From the International Stroke Genetics Consortium, Part 2: Biological Sample Collection and Storage.Battey, TW, Valant V., Kassis SB, Kourkoulis C., Lee C., Anderson CD, Falcone GJ, Jimenez-Conde J., Fernandez-Cadenas I., Pare G., Rundek T., James ML, Lemmens R., Lee TH, Tatlisumak T., Kittner SJ, Lindgren A., Mateen FJ, Berkowitz AL, Holliday EG, et al. Stroke; a journal of cerebral circulation, 2014/12/09, (2014) Read More / View Supplemental Materials
Locally disordered methylation forms the basis of intratumor methylome variation in chronic lymphocytic leukemia.Landau, DA, Clement K., Ziller MJ, Boyle P., Fan J., Gu H., Stevenson K., Sougnez C., Wang L., Li S., Kotliar D., Zhang W., Ghandi M., Garraway L., Fernandes SM, Livak KJ, Gabriel S., Gnirke A., Lander E. S., Brown JR, et al. Cancer cell, 2014/12/08, Volume 26, Issue 6, p.813-25, (2014) Read More / View Supplemental Materials
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Metabolomics of renal venous plasma from individuals with unilateral renal artery stenosis and essential hypertension.Rhee, EP, Clish CB, Pierce KA, Saad A., Lerman LO, and Textor SC Journal of hypertension, 2014/12/08, (2014) Read More / View Supplemental Materials
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Mutations in G protein β subunits promote transformation and kinase inhibitor resistance.Yoda, A., Adelmant G., Tamburini J., Chapuy B., Shindoh N., Yoda Y., Weigert O., Kopp N., Wu SC, Kim SS, Liu H., Tivey T., Christie AL, Elpek KG, Card J., Gritsman K., Gotlib J., Deininger MW, Makishima H., Turley SJ, et al. Nature medicine, 2014/12/08, (2014) Read More / View Supplemental Materials
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Improved Gene Tree Error-Correction in the Presence of Horizontal Gene Transfer.Bansal, MS, Wu YC, Alm EJ, and Kellis M. Bioinformatics (Oxford, England), 2014/12/05, (2014) Read More / View Supplemental Materials
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Biallelic Truncating Mutations in FMN2, Encoding the Actin-Regulatory Protein Formin 2, Cause Nonsyndromic Autosomal-Recessive Intellectual Disability.Law, R., Dixon-Salazar T., Jerber J., Cai N., Abbasi AA, Zaki MS, Mittal K., Gabriel SB, Rafiq MA, Khan V., Nguyen M., Ali G., Copeland B., Scott E., Vasli N., Mikhailov A., Khan MN, Andrade DM, Ayaz M., Ansar M., et al. American journal of human genetics, 2014/12/04, Volume 95, Issue 6, p.721-8, (2014) Read More / View Supplemental Materials
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BioAssay Research Database (BARD): chemical biology and probe-development enabled by structured metadata and result types.Howe, EA, De Souza A., Lahr DL, Chatwin S., Montgomery P., Alexander BR, Nguyen DT, Cruz Y., Stonich DA, Walzer G., Rose JT, Picard SC, Liu Z., Rose JN, Xiang X., Asiedu J., Durkin D., Levine J., Yang JJ, Schürer SC, et al. Nucleic acids research, 2014/12/04, (2014) Read More / View Supplemental Materials
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Deconstructing transcriptional heterogeneity in pluripotent stem cells.Kumar, RM, Cahan P., Shalek AK, Satija R., DaleyKeyser AJ, Li H., Zhang J., Pardee K., Gennert D., Trombetta JJ, Ferrante TC, Regev A., Daley GQ, and Collins JJ Nature, 2014/12/04, Volume 516, Issue 7529, p.56-61, (2014) Read More / View Supplemental Materials
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MSC-Regulated MicroRNAs Converge on the Transcription Factor FOXP2 and Promote Breast Cancer Metastasis.Cuiffo, BG, Campagne A., Bell GW, Lembo A., Orso F., Lien EC, Bhasin MK, Raimo M., Hanson SE, Marusyk A., El-Ashry D., Hematti P., Polyak K., Mechta-Grigoriou F., Mariani O., Volinia S., Vincent-Salomon A., Taverna D., and Karnoub AE Cell stem cell, 2014/12/04, Volume 15, Issue 6, p.762-74, (2014) Read More / View Supplemental Materials
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Smoking is associated with mosaic loss of chromosome Y.Dumanski, JP, Rasi C., Lönn M., Davies H., Ingelsson M., Giedraitis V., Lannfelt L., Magnusson PK, Lindgren CM, Morris AP, Cesarini D., Johannesson M., Tiensuu Janson E., Lind L., Pedersen NL, Ingelsson E., and Forsberg LA Science (New York, N.Y.), 2014/12/04, (2014) Read More / View Supplemental Materials
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Virtual karyotyping reveals greater chromosomal stability in neural cells derived by transdifferentiation than those from stem cells.Weissbein, U., Ben-David U., and Benvenisty N. Cell stem cell, 2014/12/04, Volume 15, Issue 6, p.687-91, (2014) Read More / View Supplemental Materials
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GB virus C co-infections in West African Ebola patients.Lauck, M., Bailey AL, Andersen KG, Goldberg TL, Sabeti PC, and O'Connor DH Journal of virology, 2014/12/03, (2014) Read More / View Supplemental Materials
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Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study.Gottlieb, DJ, Hek K., Chen TH, Watson NF, Eiriksdottir G., Byrne EM, Cornelis M., Warby SC, Bandinelli S., Cherkas L., Evans DS, Grabe HJ, Lahti J., Li M., Lehtimäki T., Lumley T., Marciante KD, Pérusse L., Psaty BM, Robbins J., et al. Molecular psychiatry, 2014/12/02, (2014) Read More / View Supplemental Materials
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Altered chromatin occupancy of master regulators underlies evolutionary divergence in the transcriptional landscape of erythroid differentiation.Ulirsch, JC, Lacy JN, An X., Mohandas N., Mikkelsen TS, and Sankaran VG PLoS genetics, 2014/12/01, Volume 10, Issue 12, p.e1004890, (2014) Read More / View Supplemental Materials
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CDK5 is a major regulator of the tumor suppressor DLC1.Tripathi, BK, Qian X., Mertins P., Wang D., Papageorge AG, Carr SA, and Lowy DR The Journal of cell biology, 2014/12/01, (2014) Read More / View Supplemental Materials
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A comparison of non-integrating reprogramming methods.Schlaeger, TM, Daheron L., Brickler TR, Entwisle S., Chan K., Cianci A., DeVine A., Ettenger A., Fitzgerald K., Godfrey M., Gupta D., McPherson J., Malwadkar P., Gupta M., Bell B., Doi A., Jung N., Li X., Lynes MS, Brookes E., et al. Nature biotechnology, 2014/12/01, (2014) Read More / View Supplemental Materials
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Functional optimization of gene clusters by combinatorial design and assembly.Smanski, MJ, Bhatia S., Zhao D., Park Y., B A Woodruff L., Giannoukos G., Ciulla D., Busby M., Calderon J., Nicol R., Gordon DB, Densmore D., and Voigt CA Nature biotechnology, 2014/12/01, Volume 32, Issue 12, p.1241-9, (2014) Read More / View Supplemental Materials
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Genetics of immune-mediated disorders: from genome-wide association to molecular mechanism.Kumar, V., Wijmenga C., and Xavier RJ Current opinion in immunology, 2014/12/01, Volume 31C, p.51-57, (2014) Read More / View Supplemental Materials
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Genome update of the dimorphic human pathogenic fungi causing paracoccidioidomycosis.Muñoz, JF, Gallo JE, Misas E., Priest M., Imamovic A., Young S., Zeng Q., Clay OK, McEwen JG, and Cuomo CA PLoS neglected tropical diseases, 2014/12/01, Volume 8, Issue 12, p.e3348, (2014) Read More / View Supplemental Materials
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Human Kidney Disease-causing INF2 Mutations Perturb Rho/Dia Signaling in the Glomerulus.Sun, H., Al-Romaih KI, Macrae CA, and Pollak MR EBioMedicine, 2014/12/01, Volume 1, Issue 2-3, p.107-15, (2014) Read More / View Supplemental Materials
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p53 prevents neurodegeneration by regulating synaptic genes.Merlo, P., Frost B., Peng S., Yang YJ, Park PJ, and Feany M. Proceedings of the National Academy of Sciences of the United States of America, 2014/12/01, (2014) Read More / View Supplemental Materials
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Probing small-molecule microarrays with tagged proteins in cell lysates.Pop, MS, Wassaf D., and Koehler AN Current protocols in chemical biology, 2014/12/01, Volume 6, Issue 4, p.209-20, (2014) Read More / View Supplemental Materials
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Stratification by Smoking Status Reveals an Association of CHRNA5-A3-B4 Genotype with Body Mass Index in Never Smokers.Taylor, AE, Morris RW, Fluharty ME, Bjorngaard JH, Asvold BO, Gabrielsen ME, Campbell A., Marioni R., Kumari M., Hällfors J., Männistö S., Marques-Vidal P., Kaakinen M., Cavadino A., Postmus I., Husemoen LL, Skaaby T., Ahluwalia TS, Treur JL, Willemsen G., et al. PLoS genetics, 2014/12/01, Volume 10, Issue 12, p.e1004799, (2014) Read More / View Supplemental Materials
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A shower of second hit events as the cause of multifocal renal cell carcinoma in Tuberous Sclerosis Complex.Tyburczy, ME, Jozwiak S., Malinowska IA, Chekaluk Y., Pugh TJ, Wu CL, Nussbaum RL, Seepo S., Dzik T., Kotulska K., and Kwiatkowski DJ Human molecular genetics, 2014/11/28, (2014) Read More / View Supplemental Materials
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Extensive introgression in a malaria vector species complex revealed by phylogenomics.Fontaine, MC, Pease JB, Steele A., Waterhouse RM, Neafsey DE, Sharakhov IV, Jiang X., Hall AB, Catteruccia F., Kakani E., Mitchell SN, Wu YC, Smith HA, Love RR, Lawniczak MK, Slotman MA, Emrich SJ, Hahn MW, and Besansky NJ Science (New York, N.Y.), 2014/11/27, (2014) Read More / View Supplemental Materials
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Regulation of Drosophila intestinal stem cell maintenance and differentiation by the transcription factor Escargot.Loza-Coll, MA, Southall TD, Sandall SL, Brand AH, and Jones DL The EMBO journal, 2014/11/27, (2014) Read More / View Supplemental Materials
Abstract
Age-Related Clonal Hematopoiesis Associated with Adverse Outcomes.Jaiswal, S., Fontanillas P., Flannick J., Manning A., Grauman PV, Mar BG, Lindsley RC, Mermel CH, Burtt N., Chavez A., Higgins JM, Moltchanov V., Kuo FC, Kluk MJ, Henderson B., Kinnunen L., Koistinen HA, Ladenvall C., Getz G., Correa A., et al. The New England journal of medicine, 2014/11/26, (2014) Read More / View Supplemental Materials
Abstract
Association of Sickle Cell Trait With Chronic Kidney Disease and Albuminuria in African Americans.Naik, RP, Derebail VK, Grams ME, Franceschini N., Auer PL, Peloso GM, Young BA, Lettre G., Peralta CA, Katz R., Hyacinth HI, Quarells RC, Grove ML, Bick AG, Fontanillas P., Rich SS, Smith JD, Boerwinkle E., Rosamond WD, Ito K., et al. JAMA, 2014/11/26, Volume 312, Issue 20, p.2115-2125, (2014) Read More / View Supplemental Materials
Abstract
BreaKmer: detection of structural variation in targeted massively parallel sequencing data using kmers.Abo, RP, Ducar M., Garcia EP, Thorner AR, Rojas-Rudilla V., Lin L., Sholl LM, Hahn WC, Meyerson M., Lindeman NI, Van Hummelen P., and Macconaill LE Nucleic acids research, 2014/11/26, (2014) Read More / View Supplemental Materials
Abstract
Clonal Hematopoiesis and Blood-Cancer Risk Inferred from Blood DNA Sequence.Genovese, G., Kähler AK, Handsaker RE, Lindberg J., Rose SA, Bakhoum SF, Chambert K., Mick E., Neale BM, Fromer M., Purcell SM, Svantesson O., Landén M., Höglund M., Lehmann S., Gabriel SB, Moran JL, Lander E. S., Sullivan PF, Sklar P., et al. The New England journal of medicine, 2014/11/26, (2014) Read More / View Supplemental Materials
Abstract
DNA methylation signatures link prenatal famine exposure to growth and metabolism.Tobi, EW, Goeman JJ, Monajemi R., Gu H., Putter H., Zhang Y., Slieker RC, Stok AP, Thijssen PE, Müller F., van Zwet EW, Bock C., Meissner A., Lumey LH, Eline Slagboom P., and Heijmans BT Nature communications, 2014/11/26, Volume 5, p.5592, (2014) Read More / View Supplemental Materials
Abstract
Global Proteome Turnover Analyses of the Yeasts S. cerevisiae and S. pombe.Christiano, R., Nagaraj N., Fröhlich F., and Walther TC Cell reports, 2014/11/26, (2014) Read More / View Supplemental Materials
Abstract
Targeted and genome-wide sequencing reveal single nucleotide variations impacting specificity of Cas9 in human stem cells.Yang, L., Grishin D., Wang G., Aach J., Zhang CZ, Chari R., Homsy J., Cai X., Zhao Y., Fan JB, Seidman C., Seidman J., Pu W., and Church G. Nature communications, 2014/11/26, Volume 5, p.5507, (2014) Read More / View Supplemental Materials
Abstract
Measuring missing heritability: Inferring the contribution of common variants.Golan, D., Lander E. S., and Rosset S. Proceedings of the National Academy of Sciences of the United States of America, 2014/11/24, (2014) Read More / View Supplemental Materials
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Modeling pain in vitro using nociceptor neurons reprogrammed from fibroblasts.Wainger, BJ, Buttermore ED, Oliveira JT, Mellin C., Lee S., Saber WA, Wang AJ, Ichida JK, Chiu IM, Barrett L., Huebner EA, Bilgin C., Tsujimoto N., Brenneis C., Kapur K., Rubin LL, Eggan K., and Woolf CJ Nature neuroscience, 2014/11/24, (2014) Read More / View Supplemental Materials
Abstract
A Predictive Model of Bifunctional Transcription Factor Signaling during Embryonic Tissue Patterning.Junker, JP, Peterson KA, Nishi Y., Mao J., McMahon AP, and van Oudenaarden A. Developmental cell, 2014/11/24, Volume 31, Issue 4, p.448-60, (2014) Read More / View Supplemental Materials
Abstract
In vitro alterations do not reflect a requirement for host cell cycle progression during Plasmodium liver stage infection.Hanson, KK, March S., Ng S., Bhatia S., and Mota MM Eukaryotic cell, 2014/11/21, (2014) Read More / View Supplemental Materials
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A comparative encyclopedia of DNA elements in the mouse genome.Yue, F., Cheng Y., Breschi A., Vierstra J., Wu W., Ryba T., Sandstrom R., Ma Z., Davis C., Pope BD, Shen Y., Pervouchine DD, Djebali S., Thurman RE, Kaul R., Rynes E., Kirilusha A., Marinov GK, Williams BA, Trout D., et al. Nature, 2014/11/20, Volume 515, Issue 7527, p.355-64, (2014) Read More / View Supplemental Materials
Abstract
Genetic variation in human DNA replication timing.Koren, A., Handsaker RE, Kamitaki N., Karli R., Ghosh S., Polak P., Eggan K., and McCarroll SA Cell, 2014/11/20, Volume 159, Issue 5, p.1015-26, (2014) Read More / View Supplemental Materials
Abstract
iPSC-derived dopamine neurons reveal differences between monozygotic twins discordant for Parkinson's disease.Woodard, CM, Campos BA, Kuo SH, Nirenberg MJ, Nestor MW, Zimmer M., Mosharov EV, Sulzer D., Zhou H., Paull D., Clark L., Schadt EE, Sardi SP, Rubin L., Eggan K., Brock M., Lipnick S., Rao M., Chang S., Li A., et al. Cell reports, 2014/11/20, Volume 9, Issue 4, p.1173-82, (2014) Read More / View Supplemental Materials
Abstract
A Negative Feedback Loop of Transcription Factors Specifies Alternative Dendritic Cell Chromatin States.Bornstein, C., Winter D., Barnett-Itzhaki Z., David E., Kadri S., Garber M., and Amit I. Molecular cell, 2014/11/20, (2014) Read More / View Supplemental Materials
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A role for noncoding variation in schizophrenia.Roussos, P., Mitchell AC, Voloudakis G., Fullard JF, Pothula VM, Tsang J., Stahl EA, Georgakopoulos A., Ruderfer DM, Charney A., Okada Y., Siminovitch KA, Worthington J., Padyukov L., Klareskog L., Gregersen PK, Plenge RM, Raychaudhuri S., Fromer M., Purcell SM, et al. Cell reports, 2014/11/20, Volume 9, Issue 4, p.1417-29, (2014) Read More / View Supplemental Materials
Abstract
SGK3 Mediates INPP4B-Dependent PI3K Signaling in Breast Cancer.Gasser, JA, Inuzuka H., Lau AW, Wei W., Beroukhim R., and Toker A. Molecular cell, 2014/11/20, Volume 56, Issue 4, p.595-607, (2014) Read More / View Supplemental Materials
Abstract
Novel loci associated with usual sleep duration: the CHARGE Consortium Genome-Wide Association Study.Gottlieb, DJ, Hek K., Chen TH, Watson NF, Eiriksdottir G., Byrne EM, Cornelis M., Warby SC, Bandinelli S., Cherkas L., Evans DS, Grabe HJ, Lahti J., Li M., Lehtimäki T., Lumley T., Marciante KD, Pérusse L., Psaty BM, Robbins J., et al. Molecular psychiatry, 2014/11/18, (2014) Read More / View Supplemental Materials
The draft genome sequence of the ferret (Mustela putorius furo) facilitates study of human respiratory disease.Peng, X., Alföldi J., Gori K., Eisfeld AJ, Tyler SR, Tisoncik-Go J., Brawand D., Law GL, Skunca N., Hatta M., Gasper DJ, Kelly SM, Chang J., Thomas MJ, Johnson J., Berlin AM, Lara M., Russell P., Swofford R., Turner-Maier J., et al. Nature biotechnology, 2014/11/17, (2014) Read More / View Supplemental Materials
Abstract
Long-term persistence and development of induced pancreatic beta cells generated by lineage conversion of acinar cells.Li, W., Cavelti-Weder C., Zhang Y., Clement K., Donovan S., Gonzalez G., Zhu J., Stemann M., Xu K., Hashimoto T., Yamada T., Nakanishi M., Zhang Y., Zeng S., Gifford D., Meissner A., Weir G., and Zhou Q. Nature biotechnology, 2014/11/17, (2014) Read More / View Supplemental Materials
Abstract
Rapid neurogenesis through transcriptional activation in human stem cells.Busskamp, V., Lewis NE, Guye P., Ng AH, Shipman SL, Byrne SM, Sanjana NE, Murn J., Li Y., Li S., Stadler M., Weiss R., and Church GM Molecular systems biology, 2014/11/17, Volume 10, Issue 11, p.760, (2014) Read More / View Supplemental Materials
Abstract
A recurrent de novo mutation in KCNC1 causes progressive myoclonus epilepsy.Muona, M., Berkovic SF, Dibbens LM, Oliver KL, Maljevic S., Bayly MA, Joensuu T., Canafoglia L., Franceschetti S., Michelucci R., Markkinen S., Heron SE, Hildebrand MS, Andermann E., Andermann F., Gambardella A., Tinuper P., Licchetta L., Scheffer IE, Criscuolo C., et al. Nature genetics, 2014/11/17, (2014) Read More / View Supplemental Materials
Abstract
15 years of zebrafish chemical screening.Rennekamp, AJ, and Peterson RT Current opinion in chemical biology, 2014/11/15, Volume 24C, p.58-70, (2014) Read More / View Supplemental Materials
Abstract
Mental health: depression needs large human-genetics studies.Hyman, S. Nature, 2014/11/13, Volume 515, Issue 7526, p.189-91, (2014) Read More / View Supplemental Materials
Subclonal mutations in SETBP1 confer a poor prognosis in juvenile myelomonocytic leukemia.Stieglitz, E., Troup CB, Gelston LC, Haliburton J., Chow ED, Yu KB, Akutagawa J., Taylor-Weiner AN, Liu YL, Wang YD, Beckman K., Emanuel PD, Braun BS, Abate A., Gerbing RB, Alonzo TA, and Loh M. L. Blood, 2014/11/13, (2014) Read More / View Supplemental Materials
Abstract
Synaptic, transcriptional and chromatin genes disrupted in autism.De Rubeis, S., He X., Goldberg AP, Poultney CS, Samocha K., Ercument Cicek A., Kou Y., Liu L., Fromer M., Walker S., Singh T., Klei L., Kosmicki J., Fu SC, Aleksic B., Biscaldi M., Bolton PF, Brownfeld JM, Cai J., Campbell NG, et al. Nature, 2014/11/13, Volume 515, Issue 7526, p.209-15, (2014) Read More / View Supplemental Materials
Abstract
Unencapsulated Streptococcus pneumoniae from conjunctivitis encode variant traits and belong to a distinct phylogenetic cluster.Valentino, MD, McGuire AM, Rosch JW, Bispo PJ, Burnham C., Sanfilippo CM, Carter RA, Zegans ME, Beall B., Earl AM, Tuomanen EI, Morris TW, Haas W., and Gilmore MS Nature communications, 2014/11/12, Volume 5, p.5411, (2014) Read More / View Supplemental Materials
Abstract
FASTKD2 is associated with memory and hippocampal structure in older adults.Ramanan, VK, Nho K., Shen L., Risacher SL, Kim S., McDonald BC, Farlow MR, Foroud TM, Gao S., Soininen H., Kłoszewska I., Mecocci P., Tsolaki M., Vellas B., Lovestone S., Aisen PS, Petersen RC, Jack CR Jr, Shaw LM, Trojanowski JQ, et al. Molecular psychiatry, 2014/11/11, (2014) Read More / View Supplemental Materials
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