Blog

  • Zhang lab unlocks crystal structure of new CRISPR/Cas9 genome editing tool

    Paul Goldsmith, August 27th, 2015

    In a paper published today in Cell researchers from the Broad Institute and University of Tokyo revealed the crystal structure of the Staphylococcus aureus Cas9 complex (SaCas9)—a highly efficient enzyme that overcomes one of the primary challenges to in vivo mammalian genome editing.

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  • Five Questions with Jay Bradner

    Paul Goldsmith, May 29th, 2015

    As associate director of the Broad’s Center for the Science of Therapeutics (CSofT), award-winning hematologist at Dana-Farber Cancer Institute, and a recognized pioneer in open-source drug discovery (not that he would admit to it), Jay Bradner is something of a rock star in the field of chemical biology.

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  • Fanning the flames of lupus

    Paul Goldsmith, April 23rd, 2015

    What: A team of researchers from the Massachusetts General Hospital, Broad Institute of MIT and Harvard, and the University of North Carolina has identified an inflammatory molecule that may play an essential role in the development of lupus—a chronic, painful autoimmune disease affecting more than 1.5 million Americans.

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  • Learning from Ebola

    Paul Goldsmith, March 9th, 2015

    In the fall of 2014, Ebola Zaire did for viral hemorrhagic fever what Jaws did for sharks in the summer of ‘75. The first Ebola diagnosis (and later death) on U.S. soil touched off a nationwide panic. Suddenly, Ebola was everywhere—dominating headlines, trending on social media, fueling the 24-hour news cycle. For a time, the fear and misinformation fueling the hysteria threatened to undermine relief efforts and overshadow the ongoing tragedy in West Africa.

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  • Attack, alter, evade: The immune system’s critical role in tumor destruction and adaptation

    Paul Goldsmith, January 30th, 2015

    One of the great misconceptions about cancer is that, since tumors originate from normal cells, they are able to disguise themselves from the immune system—lurking undetected and unopposed as they divide and proliferate. In reality, the immune system is no passive observer when it comes to cancer. Evidence is mounting that many tumors undergo almost constant immune attack. But just how these attacks are initiated and what their effect is on different tumor types has remained largely unexplored. Until now.

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  • Broad Paper Vids: Metabolic changes signal early development of pancreatic cancer

    Paul Goldsmith, October 3rd, 2014

    Pancreatic cancer is the tenth most common cancer in the United States, but the fourth most common cause of cancer death. This disparity is due, in part, to the disease’s elusive nature. Because the pancreas is located deep in the abdomen, symptoms often present only after cancer has spread to other places in the body. But this week, a team of researchers from the Broad, Dana-Farber Cancer Institute, MIT, and elsewhere reported the discovery of metabolic changes that indicate early development of the disease.

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  • The Rabbit Rift

    Paul Goldsmith, September 4th, 2014

    By all accounts, Pope Gregory I was quite the innovator. Along with his many liturgical accomplishments, he’s credited (somewhat apocryphally) with popularizing Gregorian chant, coining the phrase ‘bless you’ after someone sneezes, and perhaps, most unwittingly, creating one of the best experimental models for studying the evolution of domesticated animals. 

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  • Broad in the news: Ted Stanley’s extraordinary commitment to psychiatric research

    Paul Goldsmith, July 25th, 2014

    On Tuesday, July 22, the Broad Institute announced an unprecedented commitment of $650 million from philanthropist Ted Stanley to support psychiatric research. Stanley’s gift – the largest ever in psychiatric research and among the largest for scientific research in general – generated a great deal of coverage in the media.

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  • Broad Paper Vids: From biopsy to bedside

    Paul Goldsmith, May 29th, 2014

    Whole-exome sequencing—a technique that decodes the genetic information in protein-coding genes—has transformed the understanding and analysis of cancer biology, but the impact of this revolutionary technique has yet to reach patients in the clinic.

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  • Kerstin Lindblad-Toh receives major award from Swedish Research Council

    Paul Goldsmith, March 31st, 2014

    This week, Broad scientific director of vertebrate genome biology Kerstin Lindblad-Toh became one of the first recipients of a new long-term research grant from the Swedish Research Council. The program, known as Grants for Distinguished Professors, provides Swedish scientists with 10 years of flexible funding to support ambitious, long-term projects. Lindblad-Toh is one of only nine researchers selected to receive the inaugural award.

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